PANTHER Gene Information

Gene Symbol(s):

lin-12

Organism:

Caenorhabditis elegans

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Gene Name:

Protein lin-12

Gene ID:

WBGene00003001

Protein ID:

P14585

Persistent Id:

PTN001170663

Alternate Ids:

LIN12_CAEEL(UniProtKB-ID)	LIN12(Synonym)
176282(GeneID)	NM_066606(refSeq)
CE00274(WormBase_PRO)	WBGene00003001(WormBase)
R107.8(Ensembl_PRO)	R107(WormBase_TRS)
WBGene00003001(Ensembl)	126274(GI)
BX284603(EMBL)	CAA78474(EMBL-CDS)
lin-12{ECO:0000312\|WormBase:R107.8}(Symbol)	R107.8(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	NOTCH LIGAND FAMILY MEMBER (PTHR24044)
PANTHER Subfamily:	PROTEIN LIN-12 (PTHR24044:SF505)
PANTHER GO-slim Molecular Function:	signaling receptor binding
PANTHER GO-slim Biological Process:	negative regulation of Notch signaling pathway Notch signaling pathway
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	intercellular signal molecule

Pathway Categories:

Notch signaling pathway

Notch intracellular tethered fragment

Notch signaling pathway

Serrate and Notch extracellular fragment

Notch signaling pathway

Notch

Notch signaling pathway

Notch transmembrane domain fragment

Notch signaling pathway

Notch intracellular soluble fragment

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	transmembrane signaling receptor activity, protein binding, RNA polymerase II-specific DNA-binding transcription factor binding, calcium ion binding, Notch binding, DNA-binding transcription factor binding
GO BP Complete:	vulval development, regulation of cell fate specification, multicellular organism development, regulation of mesodermal cell fate specification, positive regulation of mesodermal cell fate specification, negative regulation of Notch signaling pathway, regulation of basement membrane organization, cell projection morphogenesis, regulation of vulval development, Notch signaling pathway, nematode larval development, dauer exit, cell differentiation, egg-laying behavior, sleep, cell fate specification
GO CC Complete:	nucleus, RNA polymerase II transcription regulator complex, membrane, plasma membrane, apical plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Pre-NOTCH Expression and Processing, NOTCH4 Activation and Transmission of Signal to the Nucleus, Signal Transduction, Negative regulation of NOTCH4 signaling, Pre-NOTCH Processing in Golgi, Signaling by NOTCH, Signaling by NOTCH4

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2909\|UniProtKB=Q9NYJ7	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000010975.4\|UniProtKB=A0A2I3RGF5	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000043273.1\|UniProtKB=A0A2I3SFR1	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000014462.3\|UniProtKB=A0A2I2ZIN7	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000019093.4\|UniProtKB=F6TFV4	Macaca mulatta	O
MOUSE\|MGI=MGI=1096877\|UniProtKB=O88516	Mus musculus	O
RAT\|RGD=70953\|UniProtKB=O88671	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000010483.6\|UniProtKB=E1B9I8	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000002987.5\|UniProtKB=A0A480YVK2	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000007731.4\|UniProtKB=F7DLM4	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000010746.6\|UniProtKB=A0A2I2UXY8	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845004619.1\|UniProtKB=A0A8I3MXZ5	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000049187.1\|UniProtKB=A0A6I8PC71	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000000787.4\|UniProtKB=H9G4A0	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000000415.2\|UniProtKB=A0A3B3HAS1	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000013530.2\|UniProtKB=H2MEF7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000000378.2\|UniProtKB=H2L3Y4	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-000125-4\|UniProtKB=Q9IAT6	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-980526-114\|UniProtKB=O57409	Danio rerio	O
HUMAN\|HGNC=2910\|UniProtKB=Q9NR61	Homo sapiens	O
GORGO\|Ensembl=ENSGGOG00000028605.2\|UniProtKB=G3SK70	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000014541.4\|UniProtKB=A0A5F7ZN66	Macaca mulatta	O
MOUSE\|MGI=MGI=1859388\|UniProtKB=Q9JI71	Mus musculus	O
RAT\|RGD=1309740\|UniProtKB=D3ZHH1	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000010361.4\|UniProtKB=Q0V7L8	Bos taurus	O
PIG\|Ensembl=ENSSSCG00005017001.1\|UniProtKB=A0A4X1URL1	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000013434.3\|UniProtKB=A0A9L0SLB3	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000014721.6\|UniProtKB=M3WL78	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845029137.1\|UniProtKB=A0A8I3Q0Q1	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000000198.4\|UniProtKB=A0A5F8G283	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000012601.3\|UniProtKB=F7G4X4	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010022311.1\|UniProtKB=A0A8V0ZHH9	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000003483.4\|UniProtKB=H9G7L9	Anolis carolinensis	O
XENLA\|Gene=LOC108705808\|UniProtKB=A0A8J1LM50	Xenopus laevis	O
ORYLA\|Ensembl=ENSORLG00000016743.2\|UniProtKB=H2MQC7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000018020.2\|UniProtKB=A0A3B3I4U3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-041014-73\|UniProtKB=Q1ECY3	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000012287.1\|UniProtKB=W5N3B4	lepisosteus oculatus	O
HUMAN\|HGNC=2908\|UniProtKB=O00548	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000018824.5\|UniProtKB=A0A2J8JA34	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000005504.3\|UniProtKB=G3QRX5	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000021144.4\|UniProtKB=F7HB47	Macaca mulatta	O
MOUSE\|MGI=MGI=104659\|UniProtKB=Q61483	Mus musculus	O
RAT\|RGD=70949\|UniProtKB=P97677	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000031476.4\|UniProtKB=A0A3Q1MAU6	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000027726.4\|UniProtKB=I3LNT3	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000014357.3\|UniProtKB=A0A9L0TK17	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000004661.5\|UniProtKB=A0A5F5XZN3	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845022293.1\|UniProtKB=A0A8I3S5K2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000005607.3\|UniProtKB=A0A5F8GQ05	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000015029.3\|UniProtKB=A0A6I8P7V2	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000002704.4\|UniProtKB=A0A803T388	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000010606.2\|UniProtKB=A0A3B3IHD2	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000027625.1\|UniProtKB=A0A3B3HAC3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-990415-47\|UniProtKB=Q8UWJ4	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-980526-29\|UniProtKB=Q6DI48	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015493.1\|UniProtKB=W5NEK8	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000004194.3\|UniProtKB=F7ALL8	Ciona intestinalis	O
BRAFL\|Gene=LOC118417211\|UniProtKB=A0A9J7LBM6	Branchiostoma floridae	O
CAEBR\|Gene_ORFName=CBG06809\|UniProtKB=A8X345	Caenorhabditis briggsae	LDO
IXOSC\|EnsemblGenome=ISCW020634\|UniProtKB=B7Q2M9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG80798\|UniProtKB=T1G456	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG133373\|UniProtKB=T1EI04	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG85694\|UniProtKB=T1G618	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g216602\|UniProtKB=A7SS38	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g128497\|UniProtKB=A7SR75	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_38707\|UniProtKB=A9V9N1	Monosiga brevicollis	O
GIAIC\|EnsemblGenome=GL50803_24512\|UniProtKB=A8B4D5	Giardia intestinalis	O
CHLRE\|EnsemblGenome=CHLRE_16g690095v5\|UniProtKB=A0A2K3CW78	Chlamydomonas reinhardtii	O