PANTHER Gene Information

Gene Symbol(s):

GRK3

Organism:

Homo sapiens

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Gene Name:

Beta-adrenergic receptor kinase 2

Gene ID:

HGNC:290

Protein ID:

P35626

Enhancers:

View enhancers for HUMAN|HGNC=290|UniProtKB=P35626

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002519402

Alternate Ids:

Q9UGW9(AltAccession)	ENSG00000100077(Ensembl)
CHEMBL1075166(ChEMBL)	543848(GI)
ARBK2_HUMAN(UniProtKB-ID)	ENST00000324198(Ensembl_TRS)
157(GeneID)	NM_005160(refSeq)
GRK3{ECO:0000312\|MIM:109636}(Symbol)	Beta-ARK-2(Synonym)
X69117(EMBL)	HGNC:290(HGNC)
109636(MIM)	CAA48870(EMBL-CDS)
2.7.11.15 {ECO:0000250\|UniProtKB:P26819}(EC)	ENSP00000317578(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE (PTHR24355)
PANTHER Subfamily:	BETA-ADRENERGIC RECEPTOR KINASE 2 (PTHR24355:SF17)
PANTHER GO-slim Molecular Function:	G protein-coupled receptor binding protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway protein phosphorylation
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G-protein receptor kinase

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

G protein receptor kinase

Parkinson disease

G-protein related kinase

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

G protein-coupled receptor kinase 3

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	G protein-coupled receptor binding, ATP binding, protein binding, G protein-coupled receptor kinase activity, beta-adrenergic receptor kinase activity, protein kinase activity
GO BP Complete:	desensitization of G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, signal transduction, receptor internalization
GO CC Complete:	presynapse, postsynapse, cytosol, cell projection, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Membrane Trafficking, Signal Transduction, Cargo recognition for clathrin-mediated endocytosis, GPCR downstream signalling, Clathrin-mediated endocytosis, G alpha (s) signalling events, Vesicle-mediated transport, Signaling by GPCR

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000014187.6\|UniProtKB=K7B2K4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000004757.4\|UniProtKB=G3QQ07	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=87941\|UniProtKB=Q3UYH7	Mus musculus	LDO
RAT\|RGD=2063\|UniProtKB=P26819	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000000005\|UniProtKB=P26818	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000009956.5\|UniProtKB=A0A480X2X7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000035327.3\|UniProtKB=A0A9L0RS43	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000019326.4\|UniProtKB=A0A3Q2HAD6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009926.6\|UniProtKB=M3WCD7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845028038.1\|UniProtKB=A0A8I3SBB3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010516.4\|UniProtKB=A0A5F8GHL2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000020452.3\|UniProtKB=F7G2S8	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010021212.1\|UniProtKB=A0A8V0ZBF6	Gallus gallus	LDO
XENLA\|Gene=LOC108707086\|UniProtKB=A0A1L8HQ32	Xenopus laevis	O
XENLA\|Gene=LOC108715724\|UniProtKB=A0A1L8HZZ6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6043587\|UniProtKB=A0A6I8S283	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001133.2\|UniProtKB=A0A3B3H7N3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030616-382\|UniProtKB=A0A2R8QPB8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003030.1\|UniProtKB=W5M5B5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000001450.3\|UniProtKB=F6VL21	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118425552\|UniProtKB=A0A9J7LXX0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100888242\|UniProtKB=A0A7M7LLL5	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00001709\|UniProtKB=Q09639	Caenorhabditis elegans	LDO
PRIPA\|EnsemblGenome=WBGene00104072\|UniProtKB=A0A2A6CHM7	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0260798\|UniProtKB=P32865	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP012026\|UniProtKB=A0A1S4H885	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC031284\|UniProtKB=A0A139WD85	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_194156\|UniProtKB=E9G660	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW009785\|UniProtKB=B7PZR9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG75424\|UniProtKB=T1G250	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG59012\|UniProtKB=B3S4A3	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_38629\|UniProtKB=A9V9G9	Monosiga brevicollis	LDO
PHYRM\|Gene=H3GQG0_PHYRM\|UniProtKB=H3GQG0	Phytophthora ramorum	LDO