PANTHER Gene Information

Gene Symbol(s):

VAV2

Organism:

Bos taurus

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Gene Name:

Vav guanine nucleotide exchange factor 2

Gene ID:

ENSBTAG00000004511.6

Protein ID:

A0A3Q1MQP9

Persistent Id:

PTN000720329

Alternate Ids:

A0A3Q1MQP9(Synonym)	ENSBTAT00000086853(Ensembl_TRS)
ENSBTAP00000073942(Ensembl_PRO)	A0A3Q1MQP9_BOVIN(UniProtKB-ID)
ENSBTAG00000004511(Ensembl)
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PANTHER Classification

PANTHER Family:	PROTEIN VAV (PTHR45818)
PANTHER Subfamily:	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2 (PTHR45818:SF4)
PANTHER GO-slim Molecular Function:	guanyl-nucleotide exchange factor activity
PANTHER GO-slim Biological Process:	cell migration regulation of GTPase activity
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:

Pathway Categories:

PDGF signaling pathway

Guanine nucleotide exchange factor VAV

T cell activation

Guanine nucleotide exchange factor VAV

B cell activation

Guanine nucleotide exchange factor VAV

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	phosphotyrosine residue binding, metal ion binding, guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding
GO BP Complete:	immune response-regulating cell surface receptor signaling pathway, small GTPase-mediated signal transduction, regulation of cell size, lamellipodium assembly, cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	cytoplasm, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

FCERI mediated MAPK activation, Regulation of actin dynamics for phagocytic cup formation, Signal transduction by L1, EPH-ephrin mediated repulsion of cells, G alpha (12/13) signalling events, Platelet activation, signaling and aggregation, Signal Transduction, Death Receptor Signaling, Innate Immune System, Hemostasis, FCERI mediated Ca+2 mobilization, GPVI-mediated activation cascade, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, RHOA GTPase cycle, Fcgamma receptor (FCGR) dependent phagocytosis, Axon guidance, Signaling by Receptor Tyrosine Kinases, RHO GTPase cycle, VEGFR2 mediated vascular permeability, RHOG GTPase cycle, RAC1 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, RHOC GTPase cycle, RAC2 GTPase cycle, Immune System, DAP12 interactions, DAP12 signaling, Developmental Biology, RAC3 GTPase cycle, GPCR downstream signalling, CDC42 GTPase cycle, Azathioprine ADME, Signaling by GPCR, L1CAM interactions, p75 NTR receptor-mediated signalling, NRAGE signals death through JNK, Drug ADME, Fc epsilon receptor (FCERI) signaling, Signaling by VEGF, VEGFA-VEGFR2 Pathway, Nervous system development, EPH-Ephrin signaling, Signaling by Rho GTPases

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12658\|UniProtKB=P52735	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021525.7\|UniProtKB=A0A2I3TV44	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007911.3\|UniProtKB=G3S5N5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000017214.4\|UniProtKB=I2CU78	Macaca mulatta	LDO
MOUSE\|MGI=MGI=102718\|UniProtKB=Q60992	Mus musculus	LDO
RAT\|RGD=1306285\|UniProtKB=D3ZYG0	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000005743.5\|UniProtKB=A0A287B8N4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015126.4\|UniProtKB=A0A5F5Q0A3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011529.6\|UniProtKB=M3WF96	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011337.1\|UniProtKB=A0A8I3NEZ8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001674.3\|UniProtKB=F6SQP5	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000013038.4\|UniProtKB=A0A5F8GRN7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002845.4\|UniProtKB=F6U979	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010028884.1\|UniProtKB=A0A8V1AAH7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000014720.4\|UniProtKB=H9GLK6	Anolis carolinensis	LDO
XENLA\|Gene=vav2.L\|UniProtKB=A0A8J1LHZ8	Xenopus laevis	O
XENLA\|Gene=vav2.S\|UniProtKB=A0A8J1LL69	Xenopus laevis	LDO
XENTR\|Gene=vav2\|UniProtKB=A0A8J1IPD9	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012202.2\|UniProtKB=A0A3B3HN02	Oryzias latipes	LDO
DANRE\|Gene=vav2\|UniProtKB=A0A8M9PUI9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000004506.1\|UniProtKB=W5MAI5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008711.3\|UniProtKB=F6WCA3	Ciona intestinalis	O
BRAFL\|Gene=LOC118422080\|UniProtKB=A0A9J7LM76	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC582602\|UniProtKB=A0A7M7NQJ6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC582411\|UniProtKB=A0A7M7PMI4	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00006887\|UniProtKB=Q45FX5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16186\|UniProtKB=A8XNX6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00090011\|UniProtKB=A0A2A6BGJ4	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0040068\|UniProtKB=Q9NHV9	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010292\|UniProtKB=A0A1S4H3M1	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC004356\|UniProtKB=A0A139WAM6	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_221220\|UniProtKB=E9FX29	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_323685\|UniProtKB=E9GZG4	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW014238\|UniProtKB=B7QJT0	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG193493\|UniProtKB=T1FV18	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG168451\|UniProtKB=T1F0L8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG163684\|UniProtKB=T1EUC8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG183126\|UniProtKB=T1FJ61	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG181812\|UniProtKB=T1FHD1	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g248472\|UniProtKB=A7T185	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG53249\|UniProtKB=B3RNQ4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_22586\|UniProtKB=A9UR12	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31066\|UniProtKB=A9UNJ0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33960\|UniProtKB=A9V8S2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31054\|UniProtKB=A9UR08	Monosiga brevicollis	O
PHANO\|EnsemblGenome=SNOG_14232\|UniProtKB=Q0U265	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNA05310\|UniProtKB=Q5KNU3	Cryptococcus neoformans	O