Pathway Component Details
| Name: | Guanine nucleotide exchange factor VAV (Vav) |
| Definition: | Vav, is tyrosine phosphorylated upon stimulation of T and B cells.Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Interacts with SLA, GRB2, GRB3, DOCK2 and APS. Interacts with SIAH2; without leading to its degradation. Widely expressed in hematopoietic cells but not in other cell types. |
| Category ID: | P01169 |
| Synonyms: | |
| Upstream: | |
| Downstream: |
GTPase-activating protein Rho
(Rho)
|
| Number Families/Subfamilies: | 4 |
| Number of Associated Sequences: | 20 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: | Medline:10669724 OMIM:164875 OMIM:600428 OMIM:605541 Medline:2253939 Medline:7700359 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR45818:SF1 | A0A5F8A629 | Vav guanine nucleotide exchange factor 3 | ISS | PubMed:14623913 |
| A0A8I3NC73 | Vav guanine nucleotide exchange factor 3 | ISS | PubMed:14623913 | |
| A0A8I5ZPB5 | Vav guanine nucleotide exchange factor 3 | ISS | PubMed:14623913 | |
| E1BBD2 | Vav guanine nucleotide exchange factor 3 | ISS | PubMed:14623913 | |
| F7EJL2 | Vav guanine nucleotide exchange factor 3 | ISS | PubMed:14623913 | |
| H2PZI8 | Vav guanine nucleotide exchange factor 3 | ISS | PubMed:14623913 | |
| Q9R0C8 | Guanine nucleotide exchange factor VAV3 | ISS | PubMed:14623913 | |
| Q9UKW4 | Guanine nucleotide exchange factor VAV3 | ISS | PubMed:14623913 | |
| PTHR45818:SF2 | A0A8I3NA65 | Vav guanine nucleotide exchange factor 1 | ISS | PubMed:10661401 |
| A0A8I3NA65 | Vav guanine nucleotide exchange factor 1 | ISS | PubMed:14623913 | |
| H2QF58 | Vav guanine nucleotide exchange factor 1 | ISS | PubMed:10661401 | |
| H2QF58 | Vav guanine nucleotide exchange factor 1 | ISS | PubMed:14623913 | |
| P15498 | Proto-oncogene vav | ISS | PubMed:10661401 | |
| P15498 | Proto-oncogene vav | ISS | PubMed:14623913 | |
| P27870 | Proto-oncogene vav | ISS | PubMed:10661401 | |
| P27870 | Proto-oncogene vav | ISS | PubMed:14623913 | |
| PTHR45818:SF3 | A0A1S4H3M1 | Uncharacterized protein | ISS | |
| Q45FX5 | Protein vav-1 | ISS | ||
| Q9NHV9 | Protein vav | ISS | ||
| PTHR45818:SF4 | A0A2I3TV44 | Vav guanine nucleotide exchange factor 2 | ISS | PubMed:14623913 |
| D3ZYG0 | Vav guanine nucleotide exchange factor 2 | ISS | PubMed:14623913 | |
| I2CU78 | Guanine nucleotide exchange factor VAV2 isoform 1 | ISS | PubMed:14623913 | |
| P52735 | Guanine nucleotide exchange factor VAV2 | ISS | PubMed:14623913 | |
| Q60992 | Guanine nucleotide exchange factor VAV2 | ISS | PubMed:14623913 |
