PANTHER Gene Information

Gene Symbol(s):

Vav2

Organism:

Rattus norvegicus

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Gene Name:

Vav guanine nucleotide exchange factor 2

Gene ID:

1306285

Protein ID:

D3ZYG0

Persistent Id:

PTN000518568

Alternate Ids:

D3ZYG0(Synonym)	1306285(RGD)
ENSRNOG00000007422(Ensembl)	ENSRNOP00000009893(Ensembl_PRO)
296603(GeneID)	164663858(GI)
ENSRNOT00000009893(Ensembl_TRS)	D3ZYG0_RAT(UniProtKB-ID)
NP_001100033(refSeq)
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PANTHER Classification

PANTHER Family:	PROTEIN VAV (PTHR45818)
PANTHER Subfamily:	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2 (PTHR45818:SF4)
PANTHER GO-slim Molecular Function:	guanyl-nucleotide exchange factor activity
PANTHER GO-slim Biological Process:	cell migration regulation of GTPase activity
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:

Pathway Categories:

PDGF signaling pathway

Guanine nucleotide exchange factor VAV

T cell activation

Guanine nucleotide exchange factor VAV

B cell activation

Guanine nucleotide exchange factor VAV

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	phosphotyrosine residue binding, metal ion binding, guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding
GO BP Complete:	immune response-regulating cell surface receptor signaling pathway, small GTPase-mediated signal transduction, cell projection assembly, regulation of cell size, lamellipodium assembly, cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	cytoplasm, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

FCERI mediated Ca+2 mobilization, Signaling by GPCR, Death Receptor Signaling, DAP12 signaling, L1CAM interactions, Fc epsilon receptor (FCERI) signaling, Azathioprine ADME, VEGFA-VEGFR2 Pathway, Hemostasis, Drug ADME, Cell death signalling via NRAGE, NRIF and NADE, RHO GTPase cycle, Fcgamma receptor (FCGR) dependent phagocytosis, Signal transduction by L1, RHOA GTPase cycle, RHOG GTPase cycle, FCERI mediated MAPK activation, RAC1 GTPase cycle, Regulation of actin dynamics for phagocytic cup formation, Platelet activation, signaling and aggregation, RAC2 GTPase cycle, EPH-ephrin mediated repulsion of cells, Signaling by VEGF, Signaling by Receptor Tyrosine Kinases, Innate Immune System, CDC42 GTPase cycle, Developmental Biology, RHOB GTPase cycle, DAP12 interactions, GPVI-mediated activation cascade, Nervous system development, Signaling by Rho GTPases, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, NRAGE signals death through JNK, p75 NTR receptor-mediated signalling, VEGFR2 mediated vascular permeability, Axon guidance, EPH-Ephrin signaling, GPCR downstream signalling, Immune System, G alpha (12/13) signalling events

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12658\|UniProtKB=P52735	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021525.7\|UniProtKB=A0A2I3TV44	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007911.3\|UniProtKB=G3S5N5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000017214.4\|UniProtKB=I2CU78	Macaca mulatta	LDO
MOUSE\|MGI=MGI=102718\|UniProtKB=Q60992	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000004511.6\|UniProtKB=A0A3Q1MQP9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005743.5\|UniProtKB=A0A287B8N4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015126.4\|UniProtKB=A0A5F5Q0A3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011529.6\|UniProtKB=M3WF96	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011337.1\|UniProtKB=A0A8I3NEZ8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001674.3\|UniProtKB=F6SQP5	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000013038.4\|UniProtKB=A0A5F8GRN7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002845.4\|UniProtKB=F6U979	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010028884.1\|UniProtKB=A0A8V1AAH7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000014720.4\|UniProtKB=H9GLK6	Anolis carolinensis	LDO
XENLA\|Gene=vav2.L\|UniProtKB=A0A8J1LHZ8	Xenopus laevis	O
XENLA\|Gene=vav2.S\|UniProtKB=A0A8J1LL69	Xenopus laevis	LDO
XENTR\|Gene=vav2\|UniProtKB=A0A8J1IPD9	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012202.2\|UniProtKB=A0A3B3HN02	Oryzias latipes	LDO
DANRE\|Gene=vav2\|UniProtKB=A0A8M9PUI9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000004506.1\|UniProtKB=W5MAI5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008711.3\|UniProtKB=F6WCA3	Ciona intestinalis	O
BRAFL\|Gene=LOC118422080\|UniProtKB=A0A9J7LM76	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC582602\|UniProtKB=A0A7M7NQJ6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC582411\|UniProtKB=A0A7M7PMI4	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00006887\|UniProtKB=Q45FX5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16186\|UniProtKB=A8XNX6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00090011\|UniProtKB=A0A2A6BGJ4	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0040068\|UniProtKB=Q9NHV9	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010292\|UniProtKB=A0A1S4H3M1	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC004356\|UniProtKB=A0A139WAM6	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_221220\|UniProtKB=E9FX29	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_323685\|UniProtKB=E9GZG4	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW014238\|UniProtKB=B7QJT0	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG193493\|UniProtKB=T1FV18	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG168451\|UniProtKB=T1F0L8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG163684\|UniProtKB=T1EUC8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG183126\|UniProtKB=T1FJ61	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG181812\|UniProtKB=T1FHD1	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g248472\|UniProtKB=A7T185	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG53249\|UniProtKB=B3RNQ4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_22586\|UniProtKB=A9UR12	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31066\|UniProtKB=A9UNJ0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33960\|UniProtKB=A9V8S2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31054\|UniProtKB=A9UR08	Monosiga brevicollis	O
PHANO\|EnsemblGenome=SNOG_14232\|UniProtKB=Q0U265	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNA05310\|UniProtKB=Q5KNU3	Cryptococcus neoformans	O