PANTHER Gene Information

Gene Symbol(s):

VAV2

Organism:

Gorilla gorilla gorilla

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Gene Name:

Vav guanine nucleotide exchange factor 2

Gene ID:

ENSGGOG00000007911.3

Protein ID:

G3S5N5

Persistent Id:

PTN002910861

Alternate Ids:

XM_019034114(refSeq)	G3S5N5_GORGO(UniProtKB-ID)
ENSGGOG00000007911(Ensembl)	1099310440(GI)
G3S5N5(Synonym)	CABD030067249(EMBL)
ENSGGOP00000023391(Ensembl_PRO)	ENSGGOT00000023305(Ensembl_TRS)
101124128(GeneID)
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PANTHER Classification

PANTHER Family:	PROTEIN VAV (PTHR45818)
PANTHER Subfamily:	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2 (PTHR45818:SF4)
PANTHER GO-slim Molecular Function:	guanyl-nucleotide exchange factor activity
PANTHER GO-slim Biological Process:	cell migration regulation of GTPase activity
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:

Pathway Categories:

PDGF signaling pathway

Guanine nucleotide exchange factor VAV

T cell activation

Guanine nucleotide exchange factor VAV

B cell activation

Guanine nucleotide exchange factor VAV

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	phosphotyrosine residue binding, metal ion binding, guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding
GO BP Complete:	immune response-regulating cell surface receptor signaling pathway, signal transduction, small GTPase-mediated signal transduction, regulation of small GTPase mediated signal transduction, cell projection assembly, regulation of cell size, lamellipodium assembly, cell migration, intracellular signal transduction, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	cytoplasm, cytosol, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12658\|UniProtKB=P52735	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021525.7\|UniProtKB=A0A2I3TV44	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000017214.4\|UniProtKB=I2CU78	Macaca mulatta	LDO
MOUSE\|MGI=MGI=102718\|UniProtKB=Q60992	Mus musculus	LDO
RAT\|RGD=1306285\|UniProtKB=D3ZYG0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000004511.6\|UniProtKB=A0A3Q1MQP9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005743.5\|UniProtKB=A0A287B8N4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015126.4\|UniProtKB=A0A5F5Q0A3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011529.6\|UniProtKB=M3WF96	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011337.1\|UniProtKB=A0A8I3NEZ8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001674.3\|UniProtKB=F6SQP5	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000013038.4\|UniProtKB=A0A5F8GRN7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002845.4\|UniProtKB=F6U979	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010028884.1\|UniProtKB=A0A8V1AAH7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000014720.4\|UniProtKB=H9GLK6	Anolis carolinensis	LDO
XENLA\|Gene=vav2.L\|UniProtKB=A0A8J1LHZ8	Xenopus laevis	O
XENLA\|Gene=vav2.S\|UniProtKB=A0A8J1LL69	Xenopus laevis	LDO
XENTR\|Gene=vav2\|UniProtKB=A0A8J1IPD9	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012202.2\|UniProtKB=A0A3B3HN02	Oryzias latipes	LDO
DANRE\|Gene=vav2\|UniProtKB=A0A8M9PUI9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000004506.1\|UniProtKB=W5MAI5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008711.3\|UniProtKB=F6WCA3	Ciona intestinalis	O
BRAFL\|Gene=LOC118422080\|UniProtKB=A0A9J7LM76	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC582602\|UniProtKB=A0A7M7NQJ6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC582411\|UniProtKB=A0A7M7PMI4	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00006887\|UniProtKB=Q45FX5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16186\|UniProtKB=A8XNX6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00090011\|UniProtKB=A0A2A6BGJ4	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0040068\|UniProtKB=Q9NHV9	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010292\|UniProtKB=A0A1S4H3M1	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC004356\|UniProtKB=A0A139WAM6	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_221220\|UniProtKB=E9FX29	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_323685\|UniProtKB=E9GZG4	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW014238\|UniProtKB=B7QJT0	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG193493\|UniProtKB=T1FV18	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG168451\|UniProtKB=T1F0L8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG163684\|UniProtKB=T1EUC8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG183126\|UniProtKB=T1FJ61	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG181812\|UniProtKB=T1FHD1	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g248472\|UniProtKB=A7T185	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG53249\|UniProtKB=B3RNQ4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_22586\|UniProtKB=A9UR12	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31066\|UniProtKB=A9UNJ0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33960\|UniProtKB=A9V8S2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31054\|UniProtKB=A9UR08	Monosiga brevicollis	O
PHANO\|EnsemblGenome=SNOG_14232\|UniProtKB=Q0U265	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNA05310\|UniProtKB=Q5KNU3	Cryptococcus neoformans	O