PANTHER Gene Information   
Gene Symbol(s): RAC1
Organism: Canis lupus familiaris
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Gene Name: Ras-related C3 botulinum toxin substrate 1
Gene ID: ENSCAFG00030017683
Protein ID: P62999
Persistent Id: PTN008393440
Alternate Ids:
51702786(GI) ENSCAFP00030028596(Ensembl_PRO)
NP_001003274(refSeq) 3.6.5.2 {ECO:0000250|UniProtKB:P63000}(EC)
X56390(EMBL) CAA39801(EMBL-CDS)
Q9BTB4(AltAccession) ENSCAFG00040013856(Ensembl)
Rac2(Synonym) ENSCAFT00040025732(Ensembl_TRS)
403955(GeneID) RAC1_CANLF(UniProtKB-ID)
RAC1(Symbol)
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PANTHER Classification
PANTHER Family: RHO FAMILY GTPASE (PTHR24072)
PANTHER Subfamily: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 (PTHR24072:SF395)  
PANTHER GO-slim Molecular Function: protein kinase binding
GTPase activity
carbohydrate derivative binding
anion binding
nucleotide binding
PANTHER GO-slim Biological Process: regulation of leukocyte migration
Rac protein signal transduction
cell projection assembly
regulation of cell shape
cortical cytoskeleton organization
establishment or maintenance of cell polarity
regulation of actin cytoskeleton organization
motor neuron axon guidance
cell chemotaxis
PANTHER GO-slim Cellular Component: dendritic spine
cytoskeleton
cytoplasmic vesicle
PANTHER protein class: small GTPase
Pathway Categories: VEGF signaling pathway
   Ras-related C3 botulinum toxin substrate
FGF signaling pathway
   Ras-related C3 botulinum toxin substrate
Axon guidance mediated by Slit/Robo
   Ras-related C3 botulinum toxin substrate
Huntington disease
   Ras-related C3 botulinum toxin substrate
p38 MAPK pathway
   Ras-related C3 botulinum toxin substrate
B cell activation
   Ras-related C3 botulinum toxin substrate
Axon guidance mediated by semaphorins
   Ras-related C3 botulinum toxin substrate
Cytoskeletal regulation by Rho GTPase
   Ras-related C3 Botulinum toxin substrate 1
CCKR signaling map
   RAC1-GTP
Inflammation mediated by chemokine and cytokine signaling pathway
   Ras-related C3 botulinum toxin substrate
Integrin signalling pathway
   Ras-related C3 botulinum toxin substrate
Inflammation mediated by chemokine and cytokine signaling pathway
   Cell division cycle 42
Gonadotropin-releasing hormone receptor pathway
   Rac1
T cell activation
   Ras-related C3 botulinum toxin substrate
Axon guidance mediated by netrin
   Ras-related C3 botulinum toxin substrate
Ras Pathway
   Ras-related C3 botulinum toxin substrate
EGF receptor signaling pathway
   Ras-related C3 botulinum toxin substrate
CCKR signaling map
   RAC1-GDP

GO MF Complete: GTP binding, protein kinase binding, Rho GDP-dissociation inhibitor binding, GTPase activity, G protein activity, membrane scission GTPase motor activity
GO BP Complete: regulation of cell shape, Rac protein signal transduction, motor neuron axon guidance, cell projection assembly, establishment or maintenance of cell polarity, regulation of neutrophil migration, positive regulation of bicellular tight junction assembly, actin filament organization, cell chemotaxis, cell motility, cortical cytoskeleton organization, neuron migration, regulation of actin cytoskeleton organization, positive regulation of protein phosphorylation, regulation of cell migration, semaphorin-plexin signaling pathway
GO CC Complete: nucleus, cytoskeleton, melanosome, membrane, dendritic spine, cytosol, cytoplasmic vesicle, plasma membrane, lamellipodium
Reactome Pathways: PCP/CE pathway, RHO GTPases activate PAKs, RHO GTPases activate PKNs, CD28 dependent Vav1 pathway, RHO GTPases activate CIT, Signaling by NTRK2 (TRKB), CD28 co-stimulation, Signaling by VEGF, Neutrophil degranulation, L1CAM interactions, RHO GTPases Activate WASPs and WAVEs, Signaling by PTK6, RHO GTPase cycle, Sema3A PAK dependent Axon repulsion, Developmental Biology, DAP12 signaling, NRAGE signals death through JNK, Signaling by SCF-KIT, Azathioprine ADME, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, VEGFA-VEGFR2 Pathway, Axon guidance, EPH-ephrin mediated repulsion of cells, Drug ADME, EPH-Ephrin signaling, Regulation of actin dynamics for phagocytic cup formation, Ephrin signaling, Fcgamma receptor (FCGR) dependent phagocytosis, EPHB-mediated forward signaling, Signal Transduction, Innate Immune System, PIP3 activates AKT signaling, Signaling by MET, NTRK2 activates RAC1, Intracellular signaling by second messengers, Signaling by Non-Receptor Tyrosine Kinases, Signal transduction by L1, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Costimulation by the CD28 family, VEGFR2 mediated vascular permeability, Nervous system development, MET activates RAP1 and RAC1, DSCAM interactions, Cell death signalling via NRAGE, NRIF and NADE, Signaling by Rho GTPases, MET promotes cell motility, Death Receptor Signaling, Signaling by Receptor Tyrosine Kinases, Signaling by WNT, Immune System, FCERI mediated MAPK activation, Sema4D mediated inhibition of cell attachment and migration, DAP12 interactions, MAPK6/MAPK4 signaling, p75 NTR receptor-mediated signalling, Activated NTRK2 signals through FYN, RAC1 GTPase cycle, RHO GTPases activate KTN1, Fc epsilon receptor (FCERI) signaling, GPVI-mediated activation cascade, RHO GTPases activate IQGAPs, Semaphorin interactions, Sema4D in semaphorin signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Platelet activation, signaling and aggregation, Adaptive Immune System, Signaling by NTRKs, RHO GTPases Activate NADPH Oxidases, DCC mediated attractive signaling, Beta-catenin independent WNT signaling, RHO GTPase Effectors, Hemostasis, Factors involved in megakaryocyte development and platelet production, Netrin-1 signaling, Negative regulation of the PI3K/AKT network, MAPK family signaling cascades, RHO GTPases Activate Formins