PANTHER Gene Information

Gene Symbol(s):

PSEN2

Organism:

Canis lupus familiaris

View Gene in Tree

Tree

Gene Name:

Presenilin

Gene ID:

ENSCAFG00845008023.1

Protein ID:

A0A8I3N5I6

Persistent Id:

PTN001304241

Alternate Ids:

ENSCAFP00845011021(Ensembl_PRO)	A0A8I3N5I6_CANLF(UniProtKB-ID)
ENSCAFT00845014216(Ensembl_TRS)	ENSCAFG00845008023(Ensembl)
A0A8I3N5I6(Synonym)
Show All

PANTHER Classification

PANTHER Family:	PRESENILIN (PTHR10202)
PANTHER Subfamily:	PRESENILIN-2 (PTHR10202:SF24)
PANTHER GO-slim Molecular Function:	aspartic-type endopeptidase activity
PANTHER GO-slim Biological Process:	membrane protein ectodomain proteolysis peptide metabolic process Notch signaling pathway protein processing calcium ion homeostasis
PANTHER GO-slim Cellular Component:	catalytic complex plasma membrane protein complex
PANTHER protein class:	aspartic protease

Pathway Categories:

Notch signaling pathway

Presenilin enhancer 2

Alzheimer disease-presenilin pathway

Presenilin

Alzheimer disease-amyloid secretase pathway

Presenilin

Alzheimer disease-presenilin pathway

Presenilin N-terminal fragment

Alzheimer disease-amyloid secretase pathway

Presenilin C-terminal fragment

Alzheimer disease-amyloid secretase pathway

Presenilin N-terminal fragment

Alzheimer disease-presenilin pathway

Presenilin C-terminal fragment

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	aspartic endopeptidase activity, intramembrane cleaving
GO BP Complete:	amyloid precursor protein catabolic process, Notch signaling pathway, calcium ion homeostasis, membrane protein ectodomain proteolysis, protein processing, intracellular signal transduction, amyloid-beta formation
GO CC Complete:	endoplasmic reticulum membrane, gamma-secretase complex, Golgi membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by ERBB4, Regulated proteolysis of p75NTR, Axon guidance, Nervous system development, EPH-ephrin mediated repulsion of cells, EPH-Ephrin signaling, Signal Transduction, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Signaling by Receptor Tyrosine Kinases, Nuclear signaling by ERBB4, p75 NTR receptor-mediated signalling, Developmental Biology, NRIF signals cell death from the nucleus

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9509\|UniProtKB=P49810	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000002052.7\|UniProtKB=A0A2I3SHN4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000003332.3\|UniProtKB=G3SCU1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000018525.4\|UniProtKB=F7A2D1	Macaca mulatta	LDO
MOUSE\|MGI=MGI=109284\|UniProtKB=Q61144	Mus musculus	LDO
RAT\|RGD=621060\|UniProtKB=O88777	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000013197\|UniProtKB=Q9XT96	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005010874\|UniProtKB=Q0MS45	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000008285.4\|UniProtKB=F6WAW1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000008781.5\|UniProtKB=A0A337SFA1	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000006114.4\|UniProtKB=A0A5F8GDB4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010238.4\|UniProtKB=F7AD40	Ornithorhynchus anatinus	LDO
CHICK\|Gene=PSEN2\|UniProtKB=Q90X07	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010018045.1\|UniProtKB=A0A8V0Z5X8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000006455.4\|UniProtKB=G1KFF8	Anolis carolinensis	LDO
XENLA\|Gene=psen2\|UniProtKB=O12977	Xenopus laevis	LDO
XENLA\|Gene=psen2.L\|UniProtKB=A0A1L8G7M0	Xenopus laevis	O
XENLA\|Gene=psen2.S\|UniProtKB=A0A8J0VE80	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-854877\|UniProtKB=F7C949	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000020169.2\|UniProtKB=H2N0U7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-000330-9\|UniProtKB=Q90ZE4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000015948.1\|UniProtKB=W5NG78	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002361.3\|UniProtKB=F6RA92	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118418980\|UniProtKB=A0A9J7MWD5	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC578066\|UniProtKB=A0A7M7T5N2	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00004958\|UniProtKB=Q01608	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032967\|UniProtKB=G2J6Q7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278263\|UniProtKB=A0A2A6BII2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115594\|UniProtKB=A0A2A6BL51	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00001985\|UniProtKB=O02100	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00033101\|UniProtKB=A8XEJ8	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004769\|UniProtKB=P52166	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00029955\|UniProtKB=A8X5S7	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00276783\|UniProtKB=A0A454XXP0	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0284421\|UniProtKB=O02194	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002957\|UniProtKB=Q7PR98	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC010178\|UniProtKB=D6WT91	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_205191\|UniProtKB=E9FSB0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW003378\|UniProtKB=B7P928	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW022390\|UniProtKB=B7QGI2	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW020583\|UniProtKB=B7Q2V0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG87358\|UniProtKB=T1G6P3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG114139\|UniProtKB=T1EFZ6	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG57183\|UniProtKB=B3S0V5	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_29512\|UniProtKB=A9VBA9	Monosiga brevicollis	LDO
ENTH1\|EnsemblGenome=CL6EHI_188280\|UniProtKB=C4M1A2	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0291352\|UniProtKB=Q54ET2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_87693\|UniProtKB=F0ZJS7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0292310\|UniProtKB=Q54DE8	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_51947\|UniProtKB=F1A6B3	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_15_1530\|UniProtKB=Q4QF26	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb09.160.3510\|UniProtKB=Q38F54	Trypanosoma brucei	LDO
TRIV3\|Gene_ORFName=TVAG_026700\|UniProtKB=A2DZ73	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_428310\|UniProtKB=A2G9L8	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_412920\|UniProtKB=A2F6H8	Trichomonas vaginalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_261548\|UniProtKB=B8BVL0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_268976\|UniProtKB=B8C3Y7	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GSQ0_PHYRM\|UniProtKB=H3GSQ0	Phytophthora ramorum	O
PHYRM\|Gene=H3GE34_PHYRM\|UniProtKB=H3GE34	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_02g078858v5\|UniProtKB=A0A2K3E0E4	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00119p00061920\|UniProtKB=W1NQ31	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_74G00250\|UniProtKB=A0A0K9NPJ2	Zostera marina	O
MUSAM\|EnsemblGenome=Ma05_g07460\|UniProtKB=A0A804J1Y4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_001249mg\|UniProtKB=K3XH78	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G130500\|UniProtKB=C5XH90	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb128860\|UniProtKB=A0A804N249	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb332720\|UniProtKB=B6TCG9	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0276400\|UniProtKB=A0A0P0V1R2	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g10480v3\|UniProtKB=A0A0Q3ITY7	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0257130\|UniProtKB=F2CQD9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3A02G189100\|UniProtKB=A0A3B6EFK6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G218100\|UniProtKB=A0A3B6FLQ8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G192400\|UniProtKB=A0A3B6GUU3	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_030740\|UniProtKB=A0A1U7ZEC8	Nelumbo nucifera	O
SPIOL\|Gene=LOC110795153\|UniProtKB=A0A9R0IX21	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr06g0259241\|UniProtKB=A0A251UI93	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C800422800\|UniProtKB=A0A9R1UPM9	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a006808mg\|UniProtKB=A0A022R9S5	Erythranthe guttata	O
SOLTU\|EnsemblGenome=PGSC0003DMG400028205\|UniProtKB=M1CQE1	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc10g081230.2\|UniProtKB=A0A3Q7IL79	Solanum lycopersicum	O
TOBAC\|Gene=LOC107765978\|UniProtKB=A0A1S3XK05	Nicotiana tabacum	O
TOBAC\|Gene=LOC107802357\|UniProtKB=A0A1S4AXB7	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi08g00072\|UniProtKB=F6HMV3	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K01546\|UniProtKB=A0A059A286	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra018606\|UniProtKB=M4DQ15	Brassica campestris	O
ARATH\|TAIR=locus=2025640\|UniProtKB=O64668	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107890049\|UniProtKB=A0A1U8I1H6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107948937\|UniProtKB=A0A1U8NMF4	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_025793\|UniProtKB=A0A061F038	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g013051mg\|UniProtKB=A0A067E5X1	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_013G067700v3\|UniProtKB=A0A2K1Y252	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_08G150800\|UniProtKB=A0A2C9VGG5	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_09G135600\|UniProtKB=A0A2C9VC94	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0845230\|UniProtKB=B9SY83	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_19G119800\|UniProtKB=I1N8G3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_03G006300\|UniProtKB=I1JK51	Glycine max	O
MEDTR\|EnsemblGenome=MTR_7g087200\|UniProtKB=G7L2M4	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr03_20120\|UniProtKB=A0A2I4GFG6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_4G417500\|UniProtKB=A0A0A0L3E5	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G048300\|UniProtKB=M5WAI2	Prunus persica	O
AMBTC\|EnsemblGenome=AMTR_s00154p00031240\|UniProtKB=W1PC62	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_50G00620\|UniProtKB=A0A0K9P098	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma04_g29950\|UniProtKB=A0A804IVI3	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_035617mg\|UniProtKB=K4A9R1	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3001G171500\|UniProtKB=A0A1B6QJF6	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb219250\|UniProtKB=A0A1D6GLV1	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os03g0603800\|UniProtKB=C7J054	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g14960v3\|UniProtKB=A0A0Q3RMS2	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0342160\|UniProtKB=F2EGF7	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS4D02G075300\|UniProtKB=A0A3B6JDQ4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4A02G238100\|UniProtKB=A0A3B6HYQ3	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS4B02G076800\|UniProtKB=A0A3B6IKZ6	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_005686\|UniProtKB=A0A1U8A559	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110795635\|UniProtKB=A0A9R0K3L9	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0408231\|UniProtKB=A0A251U0K1	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C400200950\|UniProtKB=A0A9R1VSY6	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a026313mg\|UniProtKB=A0A022RMU2	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_10444\|UniProtKB=A0A2G3A286	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_10442\|UniProtKB=A0A2G3A294	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400024636\|UniProtKB=M1CAI2	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc03g115075.1\|UniProtKB=A0A3Q7FSU6	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107823683\|UniProtKB=A0A1S4CXH8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107790304\|UniProtKB=A0A1S3ZTL3	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi17g00712\|UniProtKB=F6GSZ0	Vitis vinifera	LDO
BRANA\|Gene_ORFName=DARMORV10_C04P20920.1\|UniProtKB=A0A078JFQ8	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A05P15530.1\|UniProtKB=A0A078J4P4	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra018354\|UniProtKB=M4DPB3	Brassica campestris	LDO
ARATH\|TAIR=locus=2052080\|UniProtKB=Q9SIK7	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107941447\|UniProtKB=A0A1U8MY34	Gossypium hirsutum	O
GOSHI\|Gene=LOC107953480\|UniProtKB=A0A1U8P253	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_014267\|UniProtKB=A0A061FYV6	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g013935mg\|UniProtKB=A0A067FHZ3	Citrus sinensis	LDO
MANES\|EnsemblGenome=MANES_06G084500\|UniProtKB=A0A2C9VP23	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1469710\|UniProtKB=B9RLN5	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_05G020800\|UniProtKB=I1JZI3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_17G078500\|UniProtKB=I1MT67	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g109550\|UniProtKB=A0A072UQB9	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr02_07000\|UniProtKB=A0A2I4EZP0	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G039210\|UniProtKB=A0A0A0LQ93	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_5G205400\|UniProtKB=M5W9E2	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_55385\|UniProtKB=D8RGP0	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c3_30410\|UniProtKB=A9S846	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0001s0218\|UniProtKB=A0A2R6XVP7	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_003960070\|UniProtKB=A0A1Y1IH42	Klebsormidium nitens	LDO