PANTHER Gene Information   
Gene Symbol(s): psen2
Organism: Xenopus tropicalis
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Gene Name: Presenilin
Gene ID: XB-GENE-854877
Protein ID: F7C949
Persistent Id: PTN000024454
Alternate Ids:
549935(GeneID) F7C949_XENTR(UniProtKB-ID)
ENSXETG00000008548(Ensembl) 847127885(GI)
F7C949(Synonym) XM_012963058(refSeq)
ENSXETT00000018712(Ensembl_TRS) ENSXETP00000018712(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: PRESENILIN (PTHR10202)
PANTHER Subfamily: PRESENILIN-2 (PTHR10202:SF24)  
PANTHER GO-slim Molecular Function: aspartic-type endopeptidase activity
PANTHER GO-slim Biological Process: membrane protein ectodomain proteolysis
peptide metabolic process
Notch signaling pathway
protein processing
calcium ion homeostasis
PANTHER GO-slim Cellular Component: catalytic complex
plasma membrane protein complex
PANTHER protein class: aspartic protease
Pathway Categories: Notch signaling pathway
   Presenilin enhancer 2
Alzheimer disease-presenilin pathway
   Presenilin
Alzheimer disease-amyloid secretase pathway
   Presenilin
Alzheimer disease-presenilin pathway
   Presenilin N-terminal fragment
Alzheimer disease-amyloid secretase pathway
   Presenilin C-terminal fragment
Alzheimer disease-amyloid secretase pathway
   Presenilin N-terminal fragment
Alzheimer disease-presenilin pathway
   Presenilin C-terminal fragment

GO MF Complete: aspartic-type endopeptidase activity, peptidase activity, aspartic endopeptidase activity, intramembrane cleaving
GO BP Complete: Notch signaling pathway, calcium ion homeostasis, membrane protein ectodomain proteolysis, proteolysis, protein processing, amyloid-beta formation
GO CC Complete: endoplasmic reticulum membrane, membrane, gamma-secretase complex, Golgi membrane, endoplasmic reticulum, Golgi apparatus
Reactome Pathways: Signal Transduction, Nuclear signaling by ERBB4, Regulated proteolysis of p75NTR, Axon guidance, Noncanonical activation of NOTCH3, Signaling by ERBB4, NOTCH3 Activation and Transmission of Signal to the Nucleus, EPH-ephrin mediated repulsion of cells, Death Receptor Signaling, Signaling by NOTCH3, Developmental Biology, EPH-Ephrin signaling, Signaling by Receptor Tyrosine Kinases, p75 NTR receptor-mediated signalling, Nervous system development, Signaling by NOTCH