PANTHER Gene Information   
Gene Symbol(s): PSEN2
Organism: Pan troglodytes
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Gene Name: Presenilin
Gene ID: ENSPTRG00000002052.7
Protein ID: A0A2I3SHN4
Persistent Id: PTN000024445
Alternate Ids:
A0A2I3SHN4_PANTR(UniProtKB-ID) AACZ04040720(EMBL)
XP_009439855(refSeq) ENSPTRG00000002052(Ensembl)
A0A2I3SHN4(Synonym) 457790(GeneID)
ENSPTRT00000103545(Ensembl_TRS) 694892036(GI)
ENSPTRP00000076556(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: PRESENILIN (PTHR10202)
PANTHER Subfamily: PRESENILIN-2 (PTHR10202:SF24)  
PANTHER GO-slim Molecular Function: aspartic-type endopeptidase activity
PANTHER GO-slim Biological Process: membrane protein ectodomain proteolysis
peptide metabolic process
Notch signaling pathway
protein processing
calcium ion homeostasis
PANTHER GO-slim Cellular Component: catalytic complex
plasma membrane protein complex
PANTHER protein class: aspartic protease
Pathway Categories: Notch signaling pathway
   Presenilin enhancer 2
Alzheimer disease-presenilin pathway
   Presenilin
Alzheimer disease-amyloid secretase pathway
   Presenilin
Alzheimer disease-presenilin pathway
   Presenilin N-terminal fragment
Alzheimer disease-amyloid secretase pathway
   Presenilin C-terminal fragment
Alzheimer disease-amyloid secretase pathway
   Presenilin N-terminal fragment
Alzheimer disease-presenilin pathway
   Presenilin C-terminal fragment

GO MF Complete: aspartic-type endopeptidase activity, peptidase activity, aspartic endopeptidase activity, intramembrane cleaving
GO BP Complete: amyloid precursor protein catabolic process, Notch signaling pathway, calcium ion homeostasis, membrane protein ectodomain proteolysis, mitochondrion-endoplasmic reticulum membrane tethering, proteolysis, protein processing, intracellular signal transduction, regulation of calcium import into the mitochondrion, amyloid-beta formation
GO CC Complete: endoplasmic reticulum membrane, nuclear inner membrane, centrosome, membrane, gamma-secretase complex, Golgi membrane, endoplasmic reticulum, Golgi apparatus, protein-containing complex, kinetochore, plasma membrane
Reactome Pathways: -