PANTHER Gene Information   
Gene Symbol(s): VAV3
Organism: Canis lupus familiaris
View Gene in Tree
Tree
Tree
Gene Name: Vav guanine nucleotide exchange factor 3
Gene ID: ENSCAFG00845009278.1
Protein ID: A0A8I3NC73
Persistent Id: PTN000518520
Alternate Ids:
A0A8I3NC73(Synonym) ENSCAFT00845016534(Ensembl_TRS)
ENSCAFP00845012861(Ensembl_PRO) ENSCAFG00845009278(Ensembl)
A0A8I3NC73_CANLF(UniProtKB-ID)
Show All

PANTHER Classification
PANTHER Family: PROTEIN VAV (PTHR45818)
PANTHER Subfamily: GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3 (PTHR45818:SF1)  
PANTHER GO-slim Molecular Function: guanyl-nucleotide exchange factor activity
PANTHER GO-slim Biological Process: cell migration
regulation of GTPase activity
PANTHER GO-slim Cellular Component: cytoplasm
plasma membrane
PANTHER protein class:
Pathway Categories: PDGF signaling pathway
   Guanine nucleotide exchange factor VAV
T cell activation
   Guanine nucleotide exchange factor VAV
B cell activation
   Guanine nucleotide exchange factor VAV
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: metal ion binding, guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding
GO BP Complete: small GTPase-mediated signal transduction, regulation of cell size, response to xenobiotic stimulus, positive regulation of cell adhesion, DNA damage response, integrin-mediated signaling pathway, immune response-regulating cell surface receptor signaling pathway, vesicle fusion, lamellipodium assembly, neutrophil chemotaxis, positive regulation of B cell proliferation, cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, B cell receptor signaling pathway
GO CC Complete: cytoplasm, plasma membrane, immunological synapse
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Signaling by Rho GTPases, Miro GTPases and RHOBTB3, VEGFR2 mediated vascular permeability, G alpha (12/13) signalling events, Nervous system development, RHOA GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Signaling by Rho GTPases, Death Receptor Signaling, Signaling by VEGF, Signaling by Receptor Tyrosine Kinases, RHOG GTPase cycle, Immune System, FCERI mediated MAPK activation, RAC2 GTPase cycle, DAP12 interactions, Signaling by GPCR, RHO GTPase cycle, p75 NTR receptor-mediated signalling, Developmental Biology, DAP12 signaling, RAC1 GTPase cycle, NRAGE signals death through JNK, CDC42 GTPase cycle, Azathioprine ADME, GPCR downstream signalling, Fc epsilon receptor (FCERI) signaling, GPVI-mediated activation cascade, VEGFA-VEGFR2 Pathway, Axon guidance, FCERI mediated Ca+2 mobilization, Drug ADME, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, Regulation of actin dynamics for phagocytic cup formation, Platelet activation, signaling and aggregation, Fcgamma receptor (FCGR) dependent phagocytosis, Innate Immune System, Signal Transduction, Hemostasis

Orthologs