PANTHER Gene Information   
Gene Symbol(s): SIN3A
Organism: Canis lupus familiaris
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Gene Name: SIN3 transcription regulator family member A
Gene ID: ENSCAFG00845020249.1
Protein ID: A0A8I3PCR3
Persistent Id: PTN001389842
Alternate Ids:
ENSCAFT00845035718(Ensembl_TRS) ENSCAFG00845020249(Ensembl)
A0A8I3PCR3_CANLF(UniProtKB-ID) A0A8I3PCR3(Synonym)
ENSCAFP00845027945(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: SIN3B-RELATED (PTHR12346)
PANTHER Subfamily: PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A (PTHR12346:SF2)  
PANTHER GO-slim Molecular Function: transcription corepressor activity
PANTHER GO-slim Biological Process: negative regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: Sin3-type complex
PANTHER protein class: chromatin/chromatin-binding, or -regulatory protein
Pathway Categories: p53 pathway
   Histone deacetylase complex subunit Sin3
Huntington disease
   Histone deacetylase complex subunit Sin3a
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, transcription corepressor activity, transcription regulator inhibitor activity, chromatin binding
GO BP Complete: negative regulation of protein localization to nucleus, DNA replication, protein localization, positive regulation of neuron differentiation, positive regulation of defense response to virus by host, hematopoietic progenitor cell differentiation, negative regulation of circadian rhythm, cerebral cortex neuron differentiation, type I interferon-mediated signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of axon extension, in utero embryonic development, activation of innate immune response, response to methylglyoxal, cellular response to glucose stimulus, heterochromatin formation, negative regulation of apoptotic process, positive regulation of G2/M transition of mitotic cell cycle
GO CC Complete: transcription repressor complex, kinetochore, chromatin, Sin3-type complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Gene expression (Transcription), Generic Transcription Pathway, Transcriptional regulation by RUNX1, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of lipid metabolism by PPARalpha, Metabolism of lipids, Cellular response to chemical stress, Regulation of MECP2 expression and activity, Transcriptional Regulation by MECP2, Cytoprotection by HMOX1, Cellular responses to stimuli, RNA Polymerase II Transcription, Metabolism, Cellular responses to stress

Orthologs