PANTHER Gene Information   
Gene Symbol(s): Sin3a
Organism: Rattus norvegicus
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Gene Name: SIN3 transcription regulator family member A
Gene ID: 1311598
Protein ID: D3ZBP2
Persistent Id: PTN002285675
Alternate Ids:
ENSRNOT00000058685(Ensembl_TRS) NP_001102231(refSeq)
D3ZBP2(Synonym) D3ZBP2_RAT(UniProtKB-ID)
1311598(RGD) ENSRNOG00000032254(Ensembl)
ENSRNOP00000055480(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: SIN3B-RELATED (PTHR12346)
PANTHER Subfamily: PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A (PTHR12346:SF2)  
PANTHER GO-slim Molecular Function: transcription corepressor activity
PANTHER GO-slim Biological Process: negative regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: Sin3-type complex
PANTHER protein class: chromatin/chromatin-binding, or -regulatory protein
Pathway Categories: p53 pathway
   Histone deacetylase complex subunit Sin3
Huntington disease
   Histone deacetylase complex subunit Sin3a
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA binding, RNA binding, protein binding, RNA polymerase II-specific DNA-binding transcription factor binding, transcription corepressor activity, transcription regulator inhibitor activity, chromatin binding, protein-containing complex binding
GO BP Complete: cellular response to dopamine, negative regulation of protein localization to nucleus, DNA replication, protein localization, regulation of DNA-templated transcription, positive regulation of neuron differentiation, positive regulation of defense response to virus by host, hematopoietic progenitor cell differentiation, negative regulation of circadian rhythm, cerebral cortex neuron differentiation, type I interferon-mediated signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of hormone levels, regulation of axon extension, negative regulation of DNA-templated transcription, in utero embryonic development, activation of innate immune response, response to methylglyoxal, cellular response to glucose stimulus, heterochromatin formation, negative regulation of apoptotic process, cellular response to tert-butyl hydroperoxide, positive regulation of G2/M transition of mitotic cell cycle
GO CC Complete: nucleus, transcription regulator complex, transcription repressor complex, histone deacetylase complex, protein-containing complex, kinetochore, chromatin, nucleoplasm, Sin3-type complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Transcriptional regulation by RUNX1, Cellular responses to stress, Cellular responses to stimuli, Regulation of MECP2 expression and activity, SUMOylation of transcription cofactors, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Metabolism, Cellular response to chemical stress, Transcriptional Regulation by MECP2, Metabolism of lipids, Generic Transcription Pathway, SUMO E3 ligases SUMOylate target proteins, SUMOylation, Cytoprotection by HMOX1, Gene expression (Transcription), Regulation of lipid metabolism by PPARalpha

Orthologs