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comprehensive information about the evolution of protein-coding gene families, particularly
protein phylogeny, function and genetic variation impacting that function. Learn more

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Current Release: PANTHER 19.0 | 15,683 family phylogenetic trees | 144 species | News
Whole genome function views

PANTHER Gene Information

Gene Symbol(s):

GNB3

Organism:

Ornithorhynchus anatinus

View Gene in Tree

Tree

Gene Name:

G protein subunit beta 3

Gene ID:

ENSOANG00000009941.2

Protein ID:

F6RW74

Persistent Id:

PTN007676854

Alternate Ids:

F6RW74_ORNAN(UniProtKB-ID)	ENSOANT00000015757(Ensembl_TRS)
ENSOANG00000009941(Ensembl)	ENSOANP00000015754(Ensembl_PRO)
F6RW74(Synonym)
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PANTHER Classification

PANTHER Family:	GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA (PTHR19850)
PANTHER Subfamily:	GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(T) SUBUNIT BETA-3 (PTHR19850:SF31)
PANTHER GO-slim Molecular Function:	signaling receptor complex adaptor activity
PANTHER GO-slim Biological Process:	G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component:	plasma membrane protein complex extrinsic component of membrane cytoplasm catalytic complex cytoplasmic side of plasma membrane
PANTHER protein class:	heterotrimeric G-protein

Pathway Categories:

Beta3 adrenergic receptor signaling pathway

G-Protein

Wnt signaling pathway

G protein, beta subunit

Thyrotropin-releasing hormone receptor signaling pathway

G-Protein

GABA-B receptor II signaling

G protein, beta subunit

Histamine H1 receptor mediated signaling pathway

G-Protein

Inflammation mediated by chemokine and cytokine signaling pathway

G protein, beta and gamma subunit

5HT1 type receptor mediated signaling pathway

G-protein

5HT4 type receptor mediated signaling pathway

G-protein

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

Gq-protein

Dopamine receptor mediated signaling pathway

G protein, beta subunit

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G protein-activated inward rectifying potassium channel

Gonadotropin-releasing hormone receptor pathway

Gbeta

Endogenous cannabinoid signaling

G protein, beta subunit

Beta1 adrenergic receptor signaling pathway

G-Protein

PI3 kinase pathway

G protein, beta and gamma subunit

5HT2 type receptor mediated signaling pathway

G-protein

Enkephalin release

Gi-protein

Opioid proenkephalin pathway

G-protein

Enkephalin release

Gs-protein

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

G-protein, beta subunit

Opioid prodynorphin pathway

G-protein

Beta2 adrenergic receptor signaling pathway

G-Protein

Histamine H2 receptor mediated signaling pathway

G-Protein

Opioid proopiomelanocortin pathway

G-protein

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

Gi-protein

Metabotropic glutamate receptor group III pathway

Gi-protein

Cortocotropin releasing factor receptor signaling pathway

G-Protein

Metabotropic glutamate receptor group II pathway

G-protein

Oxytocin receptor mediated signaling pathway

G-Protein

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	GTPase binding, signaling receptor complex adaptor activity
GO BP Complete:	regulation of glucose metabolic process, G protein-coupled receptor signaling pathway, signal transduction, regulation of hormone metabolic process, regulation of gene expression, regulation of fat cell differentiation, cell volume homeostasis, regulation of triglyceride metabolic process, regulation of cholesterol metabolic process, regulation of phospholipid metabolic process
GO CC Complete:	dendrite, heterotrimeric G-protein complex, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

-

Orthologs

ID	Organism	Type
HUMAN\|HGNC=4400\|UniProtKB=P16520	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004592.6\|UniProtKB=H2R3A6	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002609.3\|UniProtKB=G3QJH3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000005190.4\|UniProtKB=F7CTP1	Macaca mulatta	LDO
MOUSE\|MGI=MGI=95785\|UniProtKB=Q61011	Mus musculus	LDO
RAT\|RGD=708344\|UniProtKB=P52287	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000016043.6\|UniProtKB=E1BB14	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005028775.1\|UniProtKB=F1SLU8	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000012371.6\|UniProtKB=M3WGT4	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845027447.1\|UniProtKB=A0A8I3PY64	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00030022113\|UniProtKB=P79147	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000018145.2\|UniProtKB=F7CXD0	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010023351.1\|UniProtKB=A0A1D5P7Z5	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000005792.2\|UniProtKB=H9GAL1	Anolis carolinensis	LDO
XENLA\|Gene=gnb3.S\|UniProtKB=Q7SZU2	Xenopus laevis	O
XENLA\|Gene=gnb3.L\|UniProtKB=Q7T0Y9	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-956713\|UniProtKB=Q5XGD8	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000006403.2\|UniProtKB=H2LPQ8	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040426-2280\|UniProtKB=Q6P025	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000012677.2\|UniProtKB=H2MBG0	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040718-134\|UniProtKB=Q6DH55	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000007772.1\|UniProtKB=W5MM34	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003768.3\|UniProtKB=F7AW67	Ciona intestinalis	O
BRAFL\|Gene=LOC118430472\|UniProtKB=A0A9J7NAW9	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115917973\|UniProtKB=A0A7M7HEW5	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00001679\|UniProtKB=P17343	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00026054\|UniProtKB=Q61ZF6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00114710\|UniProtKB=A0A8R1UF80	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0004623\|UniProtKB=P29829	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001506\|UniProtKB=Q7PXP3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014410\|UniProtKB=D6WLT9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_195438\|UniProtKB=E9GD03	Daphnia pulex	O
DROME\|FlyBase=FBgn0001105\|UniProtKB=P26308	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005911\|UniProtKB=Q7Q6D4	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP005913\|UniProtKB=Q7Q6D2	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP005912\|UniProtKB=Q7Q6D3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014882\|UniProtKB=D2A477	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_206575\|UniProtKB=E9FUX0	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW009711\|UniProtKB=B7Q3T6	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG92225\|UniProtKB=T1G8D2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG75178\|UniProtKB=T1G222	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG91325\|UniProtKB=T1G827	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g105798\|UniProtKB=A7S5Z1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG64010\|UniProtKB=B3RZG6	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_38561\|UniProtKB=A9V8R6	Monosiga brevicollis	O
YEAST\|SGD=S000005738\|UniProtKB=P18851	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACR097W\|UniProtKB=Q75C20	Eremothecium gossypii	O
CANAL\|CGD=CAL0000180995\|UniProtKB=A0A1D8PH43	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E01364g\|UniProtKB=Q6C7F0	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00081\|UniProtKB=Q5BH99	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G12210\|UniProtKB=Q4WVI4	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU00440\|UniProtKB=F5HH30	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_03482\|UniProtKB=A7EDU2	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_16044\|UniProtKB=Q0TWX6	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC32H8.07\|UniProtKB=Q10282	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03081\|UniProtKB=B6K398	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CND03830\|UniProtKB=Q5KI86	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_00703\|UniProtKB=A0A0D1EDL6	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_03727\|UniProtKB=E3K0E6	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_17943\|UniProtKB=F4PD00	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_000240\|UniProtKB=C4LZ87	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0277143\|UniProtKB=P36408	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_93216\|UniProtKB=F1A421	Dictyostelium purpureum	O
PARTE\|EnsemblGenome=GSPATT00013334001\|UniProtKB=A0D4A1	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_37124\|UniProtKB=B8CBT0	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G9J9_PHYRM\|UniProtKB=H3G9J9	Phytophthora ramorum	O
AMBTC\|EnsemblGenome=AMTR_s00059p00065870\|UniProtKB=U5D7V0	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_123G00150\|UniProtKB=A0A0K9Q2F3	Zostera marina	O
MUSAM\|EnsemblGenome=Ma10_g28650\|UniProtKB=A0A804L1D0	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g09460\|UniProtKB=A0A804KHQ7	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma06_g33350\|UniProtKB=A0A804JN72	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_036161mg\|UniProtKB=K4ABA4	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G142100\|UniProtKB=C5WQA4	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb052290\|UniProtKB=P49178	Zea mays	O
ORYSJ\|EnsemblGenome=Os03g0669200\|UniProtKB=Q40687	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_1g12820v3\|UniProtKB=I1GPP8	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0333760\|UniProtKB=A0A8I6X8T9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4B02G019900\|UniProtKB=W5EP05	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4A02G294000\|UniProtKB=A0A3B6HX51	Triticum aestivum	O
NELNU\|Gene=LOC104601886\|UniProtKB=A0A1U8ALW3	Nelumbo nucifera	O
NELNU\|Gene=LOC104595714\|UniProtKB=A0A1U8A019	Nelumbo nucifera	O
SPIOL\|Gene=LOC110805508\|UniProtKB=A0A9R0KCQ8	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr12g0547531\|UniProtKB=A0A251SUN2	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr10g0453161\|UniProtKB=A0A251TNA1	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500271450\|UniProtKB=A0A9R1X988	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C700377650\|UniProtKB=A0A9R1X4H2	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a008244mg\|UniProtKB=A0A022RC09	Erythranthe guttata	O
SOLTU\|Gene=GB1\|UniProtKB=P93563	Solanum tuberosum	O
SOLTU\|EnsemblGenome=PGSC0003DMG401000722\|UniProtKB=M0ZJA5	Solanum tuberosum	O
TOBAC\|Gene=LOC107760597\|UniProtKB=A0A1S3X384	Nicotiana tabacum	O
TOBAC\|Gene=LOC107820634\|UniProtKB=A0A1S4CNA1	Nicotiana tabacum	O
TOBAC\|Gene=LOC107776663\|UniProtKB=A0A1S3YJ35	Nicotiana tabacum	O
TOBAC\|Gene=GBB2_TOBAC\|UniProtKB=P93398	Nicotiana tabacum	O
TOBAC\|Gene=GBB3_TOBAC\|UniProtKB=Q40507	Nicotiana tabacum	O
TOBAC\|Gene=GBB1_TOBAC\|UniProtKB=P93397	Nicotiana tabacum	O
TOBAC\|Gene=LOC107793273\|UniProtKB=A0A1S4A324	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi03g00343\|UniProtKB=D7TQ08	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_I01264\|UniProtKB=A0A059APK8	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00083586001\|UniProtKB=A0A078I813	Brassica napus	O
BRACM\|EnsemblGenome=Bra034628\|UniProtKB=M4F0N3	Brassica campestris	O
BRACM\|EnsemblGenome=Bra017658\|UniProtKB=M4DMC5	Brassica campestris	O
BRACM\|EnsemblGenome=Bra011536\|UniProtKB=M4D4X9	Brassica campestris	O
ARATH\|TAIR=locus=2139489\|UniProtKB=P49177	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107894229\|UniProtKB=A0A1U8IF42	Gossypium hirsutum	O
GOSHI\|Gene=LOC107927977\|UniProtKB=A0A1U8LMB9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107908775\|UniProtKB=A0A1U8JTC9	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_006901\|UniProtKB=A0A061E6Y1	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g016458mg\|UniProtKB=A0A067E1X3	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_009G115300v3\|UniProtKB=B9HRN9	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_004G153700v3\|UniProtKB=B9H0Q0	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_17G100500\|UniProtKB=A0A2C9U6P8	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_15G164000\|UniProtKB=A0A2C9UGN5	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1674940\|UniProtKB=B9RBE4	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_11G118500\|UniProtKB=I1LJE1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_12G043900\|UniProtKB=I1LQ45	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G013000\|UniProtKB=I1K777	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_04G013100\|UniProtKB=C6THC3	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g116500\|UniProtKB=G7J6K3	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr16_18100\|UniProtKB=A0A2I4FZ53	Juglans regia	O
JUGRE\|EnsemblGenome=Jr13_07280\|UniProtKB=A0A2I4GVB3	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_7G267960\|UniProtKB=A0A0A0K4B7	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_8G098100\|UniProtKB=M5VM49	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_142121\|UniProtKB=D8QYQ4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_440157\|UniProtKB=D8R8Y3	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c2_6210\|UniProtKB=A0A2K1L0G1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c1_35990\|UniProtKB=A0A2K1LB50	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0056s0121\|UniProtKB=A0A2R6WUZ6	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_008660040\|UniProtKB=A0A1Y1IMH6	Klebsormidium nitens	O