PANTHER Gene Information   
Gene Symbol(s): VAV1
Organism: Sus scrofa
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Gene Name: Proto-oncogene vav
Gene ID: ENSSSCG00000013553.4
Protein ID: A0A286ZQX2
Persistent Id: PTN001481879
Alternate Ids:
DQIR01094955(EMBL) HDA50431(EMBL-CDS)
A0A286ZQX2_PIG(UniProtKB-ID) ENSSSCG00000013553(Ensembl)
ENSSSCT00000039776(Ensembl_TRS) A0A286ZQX2(Synonym)
ENSSSCP00000033977(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: PROTEIN VAV (PTHR45818)
PANTHER Subfamily: PROTO-ONCOGENE VAV (PTHR45818:SF2)  
PANTHER GO-slim Molecular Function: guanyl-nucleotide exchange factor activity
PANTHER GO-slim Biological Process: cell migration
regulation of GTPase activity
PANTHER GO-slim Cellular Component: cytoplasm
PANTHER protein class:
Pathway Categories: PDGF signaling pathway
   Guanine nucleotide exchange factor VAV
T cell activation
   Guanine nucleotide exchange factor VAV
Inflammation mediated by chemokine and cytokine signaling pathway
   Guanine nucleotide exchange factor
B cell activation
   Guanine nucleotide exchange factor VAV
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: phosphotyrosine residue binding, phosphorylation-dependent protein binding, metal ion binding, guanyl-nucleotide exchange factor activity
GO BP Complete: G protein-coupled receptor signaling pathway, T cell costimulation, small GTPase-mediated signal transduction, regulation of cell size, natural killer cell mediated cytotoxicity, positive regulation of natural killer cell mediated cytotoxicity, T cell differentiation, reactive oxygen species metabolic process, integrin-mediated signaling pathway, immune response-regulating cell surface receptor signaling pathway, phagocytosis, neutrophil chemotaxis, natural killer cell activation, cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete: cell-cell junction, cytoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: GPVI-mediated activation cascade, Fcgamma receptor (FCGR) dependent phagocytosis, FCERI mediated MAPK activation, Regulation of actin dynamics for phagocytic cup formation, Erythropoietin activates RAS, Signal Transduction, Platelet activation, signaling and aggregation, Signaling by Rho GTPases, p75 NTR receptor-mediated signalling, Cytokine Signaling in Immune system, NRAGE signals death through JNK, Adaptive Immune System, Costimulation by the CD28 family, CD28 dependent Vav1 pathway, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Fc epsilon receptor (FCERI) signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Signaling by Interleukins, Azathioprine ADME, Intracellular signaling by second messengers, Signaling by VEGF, Signaling by SCF-KIT, Drug ADME, VEGFA-VEGFR2 Pathway, Innate Immune System, CD28 co-stimulation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, VEGFR2 mediated vascular permeability, RHOG GTPase cycle, RAC1 GTPase cycle, RHOA GTPase cycle, Signaling by GPCR, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, RAC2 GTPase cycle, RHO GTPase cycle, Hemostasis, Regulation of signaling by CBL, Death Receptor Signaling, G alpha (12/13) signalling events, Negative regulation of the PI3K/AKT network, Immune System, GPCR downstream signalling, FCERI mediated Ca+2 mobilization, Signaling by Receptor Tyrosine Kinases, Cell death signalling via NRAGE, NRIF and NADE, Signaling by Erythropoietin, PIP3 activates AKT signaling, Signaling by the B Cell Receptor (BCR)

Orthologs