PANTHER Gene Information

Gene Symbol(s):

vav1

Organism:

Xenopus tropicalis

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Gene Name:

Proto-oncogene vav isoform X1

Gene ID:

XB-GENE-6074281

Protein ID:

A0A6I8SUJ4

Persistent Id:

PTN000518552

Alternate Ids:

A0A6I8SUJ4(Synonym)	XP_002940062(refSeq)
ENSXETG00000007366(Ensembl)	A0A6I8SUJ4_XENTR(UniProtKB-ID)
100497964(GeneID)	1043432775(GI)
ENSXETP00000096815(Ensembl_PRO)	ENSXETT00000078521(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	PROTEIN VAV (PTHR45818)
PANTHER Subfamily:	PROTO-ONCOGENE VAV (PTHR45818:SF2)
PANTHER GO-slim Molecular Function:	guanyl-nucleotide exchange factor activity
PANTHER GO-slim Biological Process:	cell migration regulation of GTPase activity
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:

Pathway Categories:

PDGF signaling pathway

Guanine nucleotide exchange factor VAV

T cell activation

Guanine nucleotide exchange factor VAV

Inflammation mediated by chemokine and cytokine signaling pathway

Guanine nucleotide exchange factor

B cell activation

Guanine nucleotide exchange factor VAV

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	metal ion binding, guanyl-nucleotide exchange factor activity
GO BP Complete:	immune response-regulating cell surface receptor signaling pathway, signal transduction, small GTPase-mediated signal transduction, cell migration, intracellular signal transduction, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signal Transduction, Innate Immune System, Signaling by Rho GTPases, Signaling by VEGF, CD28 dependent Vav1 pathway, G alpha (12/13) signalling events, Costimulation by the CD28 family, FCERI mediated MAPK activation, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Erythropoietin activates RAS, CD28 co-stimulation, Death Receptor Signaling, Cytokine Signaling in Immune system, Signaling by Interleukins, Adaptive Immune System, GPVI-mediated activation cascade, VEGFA-VEGFR2 Pathway, Fc epsilon receptor (FCERI) signaling, Signaling by SCF-KIT, Azathioprine ADME, Cell death signalling via NRAGE, NRIF and NADE, FCERI mediated Ca+2 mobilization, Drug ADME, Hemostasis, Immune System, RHOG GTPase cycle, RHO GTPase cycle, GPCR downstream signalling, RHOA GTPase cycle, RAC2 GTPase cycle, VEGFR2 mediated vascular permeability, Interleukin-3, Interleukin-5 and GM-CSF signaling, Signaling by Erythropoietin, RAC1 GTPase cycle, Signaling by Receptor Tyrosine Kinases, p75 NTR receptor-mediated signalling, Platelet activation, signaling and aggregation, NRAGE signals death through JNK, Signaling by GPCR

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12657\|UniProtKB=P15498	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010378.4\|UniProtKB=H2QF58	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012257.3\|UniProtKB=G3R994	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000019314.4\|UniProtKB=A0A1D5RF06	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98923\|UniProtKB=P27870	Mus musculus	LDO
RAT\|RGD=3951\|UniProtKB=P54100	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000039160\|UniProtKB=Q08DN7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000013553.4\|UniProtKB=A0A286ZQX2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014896.3\|UniProtKB=F6VK33	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000005052.6\|UniProtKB=M3W3D5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845008896.1\|UniProtKB=A0A8I3NA65	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002314.5\|UniProtKB=F7A3L2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000014870.3\|UniProtKB=F6XXJ5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003064.1\|UniProtKB=A0A8V0XJF3	Gallus gallus	LDO
XENLA\|Gene=LOC108705008\|UniProtKB=A0A8J1ME72	Xenopus laevis	O
XENLA\|Gene=vav1.L\|UniProtKB=Q6DCX0	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000009385.2\|UniProtKB=A0A3B3HII6	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000007259.1\|UniProtKB=W5MK78	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008711.3\|UniProtKB=F6WCA3	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118422080\|UniProtKB=A0A9J7LM76	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582602\|UniProtKB=A0A7M7NQJ6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC582411\|UniProtKB=A0A7M7PMI4	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00006887\|UniProtKB=Q45FX5	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG16186\|UniProtKB=A8XNX6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00090011\|UniProtKB=A0A2A6BGJ4	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0040068\|UniProtKB=Q9NHV9	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010292\|UniProtKB=A0A1S4H3M1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC004356\|UniProtKB=A0A139WAM6	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_221220\|UniProtKB=E9FX29	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_323685\|UniProtKB=E9GZG4	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW014238\|UniProtKB=B7QJT0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG193493\|UniProtKB=T1FV18	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG168451\|UniProtKB=T1F0L8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG163684\|UniProtKB=T1EUC8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG183126\|UniProtKB=T1FJ61	helobdella robusta	LDO
HELRO\|EnsemblGenome=HelroG181812\|UniProtKB=T1FHD1	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g248472\|UniProtKB=A7T185	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG53249\|UniProtKB=B3RNQ4	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_22586\|UniProtKB=A9UR12	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31066\|UniProtKB=A9UNJ0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33960\|UniProtKB=A9V8S2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31054\|UniProtKB=A9UR08	Monosiga brevicollis	LDO
PHANO\|EnsemblGenome=SNOG_14232\|UniProtKB=Q0U265	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CNA05310\|UniProtKB=Q5KNU3	Cryptococcus neoformans	LDO