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Gene Symbol(s):
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Grk2
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| Organism: |
Rattus norvegicus |
| View Gene in Tree |
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| Gene Name: |
Beta-adrenergic receptor kinase 1
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| Gene ID: |
2062
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| Protein ID: |
P26817
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| Persistent Id: |
PTN000683236 |
| Alternate Ids: |
| Grk2{ECO:0000312|RGD:2062}(Symbol) |
G-protein-coupled receptor kinase 2 {ECO:0000312|RGD:2062}(Synonym) |
| 2062(RGD) |
AAA40802(EMBL-CDS) |
| 25238(GeneID) |
114153(GI) |
| ARBK1_RAT(UniProtKB-ID) |
M87854(EMBL) |
| 2.7.11.15 {ECO:0000269|PubMed:1403099}(EC) |
NM_012776(refSeq) |
CHEMBL4105719(ChEMBL) |
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Show All
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| GO MF Complete: |
G protein-coupled receptor binding, ATP binding, scaffold protein binding, protein binding, ubiquitin protein ligase binding, G protein-coupled receptor kinase activity, beta-adrenergic receptor kinase activity, delta-type opioid receptor binding, protein kinase activity, protein serine/threonine kinase activity, Edg-2 lysophosphatidic acid receptor binding, kappa-type opioid receptor binding
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| GO BP Complete: |
response to caloric restriction, cardiac muscle contraction, tachykinin receptor signaling pathway, follicle-stimulating hormone signaling pathway, cellular response to glucose stimulus, regulation of inositol trisphosphate biosynthetic process, negative regulation of peptidyl-serine phosphorylation, G protein-coupled receptor signaling pathway, response to leptin, response to organic cyclic compound, response to hydrogen peroxide, cellular response to phorbol 13-acetate 12-myristate, positive regulation of catecholamine secretion, cellular response to epidermal growth factor stimulus, viral genome replication, peptidyl-serine phosphorylation, positive regulation of interleukin-6 production, positive regulation of muscle cell apoptotic process, receptor internalization, cellular response to organic cyclic compound, peptidyl-threonine phosphorylation, maintenance of protein location in nucleus, symbiont entry into host cell, positive regulation of vasoconstriction, negative regulation of cellular response to insulin stimulus, vasodilation, protein phosphorylation, negative regulation of striated muscle contraction, negative regulation of G protein-coupled receptor signaling pathway, response to oxidative stress, heart development, positive regulation of vascular associated smooth muscle cell proliferation, negative regulation of the force of heart contraction by chemical signal, negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, positive regulation of fibroblast proliferation, cellular response to catecholamine stimulus, cellular response to chemokine, negative regulation of relaxation of smooth muscle, response to muscle activity, oligodendrocyte differentiation, signal transduction, negative regulation of D-glucose import, regulation of the force of heart contraction, desensitization of G protein-coupled receptor signaling pathway, cellular response to rapamycin, negative regulation of peptidyl-threonine phosphorylation, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of excitatory postsynaptic potential, negative regulation of apoptotic signaling pathway
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| GO CC Complete: |
postsynaptic density, cytoplasmic side of mitochondrial outer membrane, cell projection, plasma membrane, nucleus, caveola, presynapse, postsynapse, cytoplasm, dendritic shaft, membrane, dendritic spine, cytosol, glutamatergic synapse, basolateral plasma membrane, apical plasma membrane, axon
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| Reactome Pathways: |
Hedgehog 'on' state, Signaling by GPCR, DAG and IP3 signaling, Signaling by Hedgehog, PLC beta mediated events, Signal Transduction, Calmodulin induced events, Ca-dependent events, CaM pathway, Opioid Signalling, Cargo recognition for clathrin-mediated endocytosis, G alpha (i) signalling events, GPCR downstream signalling, G alpha (s) signalling events, G alpha (q) signalling events, G-protein mediated events, Vesicle-mediated transport, Intracellular signaling by second messengers, Activation of SMO, Membrane Trafficking, Clathrin-mediated endocytosis
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