PANTHER Gene Information   
Gene Symbol(s): Grk2
Organism: Mus musculus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Beta-adrenergic receptor kinase 1
Gene ID: MGI:87940
Protein ID: Q99MK8
Persistent Id: PTN000683235
Alternate Ids:
2.7.11.15 {ECO:0000250|UniProtKB:P26817}(EC) 47605537(GI)
MGI:87940(MGI) CHEMBL3711486(ChEMBL)
AAH03196(EMBL-CDS) ENSMUSG00000024858(Ensembl)
ENSMUSP00000086114(Ensembl_PRO) NP_001277747(refSeq)
ENSMUST00000088737(Ensembl_TRS) AF333028(EMBL)
G-protein-coupled receptor kinase 2 {ECO:0000312|MGI:MGI:87940}(Synonym) Grk2{ECO:0000312|MGI:MGI:87940}(Symbol)
Q99LL8(AltAccession) 110355(GeneID)
ARBK1_MOUSE(UniProtKB-ID)
Show All

PANTHER Classification
PANTHER Family: G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE (PTHR24355)
PANTHER Subfamily: BETA-ADRENERGIC RECEPTOR KINASE 1 (PTHR24355:SF22)  
PANTHER GO-slim Molecular Function: G protein-coupled receptor binding
protein serine/threonine kinase activity
PANTHER GO-slim Biological Process: regulation of biological quality
regulation of heart contraction
negative regulation of signal transduction
regulation of G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway
protein phosphorylation
PANTHER GO-slim Cellular Component:
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   G-protein receptor kinase
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   G protein receptor kinase
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
   G protein-coupled receptor kinase 2
Inflammation mediated by chemokine and cytokine signaling pathway
   G-protein receptor kinase
Parkinson disease
   G-protein related kinase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: G protein-coupled receptor binding, ATP binding, scaffold protein binding, protein binding, ubiquitin protein ligase binding, G protein-coupled receptor kinase activity, beta-adrenergic receptor kinase activity, delta-type opioid receptor binding, protein kinase activity, protein serine/threonine kinase activity, Edg-2 lysophosphatidic acid receptor binding, kappa-type opioid receptor binding
GO BP Complete: symbiont entry into host cell, positive regulation of vasoconstriction, negative regulation of cellular response to insulin stimulus, vasodilation, protein phosphorylation, negative regulation of striated muscle contraction, cardiac muscle contraction, tachykinin receptor signaling pathway, follicle-stimulating hormone signaling pathway, negative regulation of G protein-coupled receptor signaling pathway, response to oxidative stress, heart development, positive regulation of vascular associated smooth muscle cell proliferation, negative regulation of the force of heart contraction by chemical signal, cellular response to glucose stimulus, negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, positive regulation of fibroblast proliferation, negative regulation of peptidyl-serine phosphorylation, cellular response to chemokine, negative regulation of relaxation of smooth muscle, oligodendrocyte differentiation, G protein-coupled receptor signaling pathway, negative regulation of D-glucose import, response to organic cyclic compound, regulation of the force of heart contraction, positive regulation of catecholamine secretion, desensitization of G protein-coupled receptor signaling pathway, negative regulation of peptidyl-threonine phosphorylation, negative regulation of apoptotic process, cellular response to epidermal growth factor stimulus, viral genome replication, positive regulation of excitatory postsynaptic potential, peptidyl-serine phosphorylation, positive regulation of interleukin-6 production, positive regulation of muscle cell apoptotic process, receptor internalization, peptidyl-threonine phosphorylation, maintenance of protein location in nucleus
GO CC Complete: postsynaptic density, cytoplasmic side of mitochondrial outer membrane, plasma membrane, caveola, presynapse, postsynapse, cytoplasm, dendritic shaft, membrane, dendritic spine, cilium, cytosol, glutamatergic synapse, basolateral plasma membrane, apical plasma membrane, axon
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: G alpha (i) signalling events, Signal Transduction, G alpha (s) signalling events, Intracellular signaling by second messengers, G alpha (q) signalling events, G-protein mediated events, Hedgehog 'on' state, GPCR downstream signalling, Signaling by Hedgehog, Membrane Trafficking, Calmodulin induced events, Ca-dependent events, CaM pathway, Cargo recognition for clathrin-mediated endocytosis, Vesicle-mediated transport, PLC beta mediated events, DAG and IP3 signaling, Clathrin-mediated endocytosis, Signaling by GPCR, Opioid Signalling, Activation of SMO

Orthologs