PANTHER Gene Information   
Gene Symbol(s): ERCC2
Organism: Bos taurus
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Gene Name: General transcription and DNA repair factor IIH helicase subunit XPD
Gene ID: ENSBTAG00000002072
Protein ID: A6QLJ0
Persistent Id: PTN000158258
Alternate Ids:
ENSBTAP00000002680(Ensembl_PRO) Xeroderma pigmentosum group D-complementing protein(Synonym)
ERCC2(Symbol) 100125238(GeneID)
BC147982(EMBL) ENSBTAT00000002680(Ensembl_TRS)
ENSBTAG00000002072(Ensembl) AAI47983(EMBL-CDS)
3.6.4.12(EC) 151556394(GI)
ERCC2_BOVIN(UniProtKB-ID) NP_001096787(refSeq)
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PANTHER Classification
PANTHER Family: DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER (PTHR11472)
PANTHER Subfamily: GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD (PTHR11472:SF1)  
PANTHER GO-slim Molecular Function: DNA helicase activity
damaged DNA binding
PANTHER GO-slim Biological Process: positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule metabolic process
transcription by RNA polymerase II
regulation of DNA recombination
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: DNA helicase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP hydrolysis activity, double-stranded DNA helicase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, four-way junction helicase activity, forked DNA-dependent helicase activity, cohesin loader activity, damaged DNA binding, 5'-3' DNA helicase activity, DNA binding, ATP binding, DNA helicase activity, DNA clamp loader activity, ATP-dependent H2AZ histone chaperone activity, protein binding, metal ion binding, ATP-dependent H3-H4 histone complex chaperone activity, 4 iron, 4 sulfur cluster binding, single-stranded 3'-5' DNA helicase activity, protein-macromolecule adaptor activity, chromatin extrusion motor activity, isomerase activity
GO BP Complete: multicellular organism growth, embryonic cleavage, transcription elongation by RNA polymerase I, UV protection, determination of adult lifespan, transcription-coupled nucleotide-excision repair, post-embryonic development, nucleotide-excision repair, transcription by RNA polymerase II, chromosome segregation, transcription initiation at RNA polymerase II promoter, spinal cord development, erythrocyte maturation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), response to oxidative stress, chromatin remodeling, in utero embryonic development, DNA duplex unwinding, central nervous system myelin formation, hair cell differentiation, bone mineralization, regulation of mitotic cell cycle phase transition, positive regulation of mitotic recombination, insulin-like growth factor receptor signaling pathway, hematopoietic stem cell differentiation, hair follicle maturation, regulation of transcription by RNA polymerase II, intrinsic apoptotic signaling pathway by p53 class mediator, extracellular matrix organization, hematopoietic stem cell proliferation, chromatin looping
GO CC Complete: MMXD complex, nucleus, transcription factor TFIID complex, cytoplasm, transcription factor TFIIH core complex, spindle, cytosol, transcription factor TFIIH holo complex, CAK-ERCC2 complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: RNA Pol II CTD phosphorylation and interaction with CE, Gene expression (Transcription), RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Termination, Dual incision in TC-NER, DNA Repair, RNA Polymerase I Promoter Escape, Gap-filling DNA repair synthesis and ligation in TC-NER, Transcriptional Regulation by TP53, mRNA Capping, TP53 Regulates Transcription of DNA Repair Genes, Dual Incision in GG-NER, Generic Transcription Pathway, Metabolism of RNA, Transcription-Coupled Nucleotide Excision Repair (TC-NER), RNA Polymerase II Transcription, Formation of the Early Elongation Complex, Formation of TC-NER Pre-Incision Complex, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase I Promoter Clearance, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription Initiation, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription Elongation, Nucleotide Excision Repair, Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), RNA Polymerase II Pre-transcription Events

Orthologs