PANTHER Gene Information

Gene Symbol(s):

IscW_ISCW000859

Organism:

Ixodes scapularis

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Gene Name:

General transcription and DNA repair factor IIH helicase subunit XPD

Gene ID:

ISCW000859

Protein ID:

B7P2J8

Persistent Id:

PTN000895469

Alternate Ids:

ISCW000859-RA(Ensembl_TRS)	XM_002402414(refSeq)
ABJB010785291(EMBL)	B7P2J8(Synonym)
ISCW000859(Ensembl)	EEC00820(EMBL-CDS)
ISCW000859-PA(Ensembl_PRO)	240976653(GI)
B7P2J8_IXOSC(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER (PTHR11472)
PANTHER Subfamily:	GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD (PTHR11472:SF1)
PANTHER GO-slim Molecular Function:	DNA helicase activity damaged DNA binding
PANTHER GO-slim Biological Process:	positive regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process transcription by RNA polymerase II regulation of DNA recombination
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	DNA helicase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	double-stranded DNA helicase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, helicase activity, four-way junction helicase activity, forked DNA-dependent helicase activity, damaged DNA binding, DNA binding, ATP binding, DNA helicase activity, metal ion binding, 4 iron, 4 sulfur cluster binding, single-stranded 3'-5' DNA helicase activity, hydrolase activity, isomerase activity
GO BP Complete:	DNA repair, DNA duplex unwinding, positive regulation of mitotic recombination, nucleotide-excision repair, transcription by RNA polymerase II, DNA damage response
GO CC Complete:	nucleus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3434\|UniProtKB=P18074	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000011149.5\|UniProtKB=G2HHJ3	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000014419.4\|UniProtKB=H9Z687	Macaca mulatta	LDO
MOUSE\|MGI=MGI=95413\|UniProtKB=O08811	Mus musculus	LDO
RAT\|RGD=1309109\|UniProtKB=D3ZEG9	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002072\|UniProtKB=A6QLJ0	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000039929.3\|UniProtKB=A0A286ZVC7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000036849.3\|UniProtKB=A0A3Q2IGZ9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000002679.6\|UniProtKB=M3VYY5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845005380.1\|UniProtKB=A0A8I3MQT0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000021549.4\|UniProtKB=F7DF10	Monodelphis domestica	LDO
XENLA\|Gene=ercc2.L\|UniProtKB=A0A8J0TIY0	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-949792\|UniProtKB=Q66II2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001570.2\|UniProtKB=A0A3B3HKG0	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-997\|UniProtKB=F1Q5E7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000014383.1\|UniProtKB=W5NAQ1	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118415453\|UniProtKB=A0A9J7L4U3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC575323\|UniProtKB=A0A7M7PS76	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00021752\|UniProtKB=Q9N3L2	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00035859\|UniProtKB=A8XML3	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00101686\|UniProtKB=A0A2A6CCS3	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0261850\|UniProtKB=Q7KVP9	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002988\|UniProtKB=Q7QD77	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC002825\|UniProtKB=D6WI90	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_324413\|UniProtKB=E9H1D4	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG105484\|UniProtKB=T1EDV5	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g180316\|UniProtKB=A7RNX6	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG50379\|UniProtKB=B3RYU5	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_34274\|UniProtKB=A9VAM5	Monosiga brevicollis	LDO
YEAST\|SGD=S000000973\|UniProtKB=P06839	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AGR114C\|UniProtKB=Q74ZT4	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000192893\|UniProtKB=A0A1D8PQH0	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F20746g\|UniProtKB=Q6C0Y5	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_09436\|UniProtKB=C8VRA9	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_1G13910\|UniProtKB=Q4WS59	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU01625\|UniProtKB=Q7RXF5	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_09606\|UniProtKB=A7EW97	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_09475\|UniProtKB=Q0UFI9	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC1D4.12\|UniProtKB=P26659	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00995\|UniProtKB=B6JX67	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNA05570\|UniProtKB=Q5KNR6	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_04151\|UniProtKB=A0A0D1C1C2	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_21591\|UniProtKB=H6QRX6	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_29908\|UniProtKB=F4P2D7	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_197850\|UniProtKB=C4M8K7	Entamoeba histolytica	LDO
ENTH1\|EnsemblGenome=CL6EHI_132410\|UniProtKB=C4M8Q4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0267414\|UniProtKB=Q55G81	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_50564\|UniProtKB=F0ZZ26	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_24_2280\|UniProtKB=Q4QAA2	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.8.5980\|UniProtKB=Q57YJ9	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_4328\|UniProtKB=A8BYS3	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_442190\|UniProtKB=A2F1W2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_023300\|UniProtKB=A2G2G8	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_0934100\|UniProtKB=Q8I2H7	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00035341001\|UniProtKB=A0C5Z5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036512001\|UniProtKB=A0CAB5	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_268868\|UniProtKB=B8C2D9	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G8C6_PHYRM\|UniProtKB=H3G8C6	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_17g706300v5\|UniProtKB=A0A2K3CPA2	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00025p00038580\|UniProtKB=W1PQJ6	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_166G00350\|UniProtKB=A0A0K9PVQ8	Zostera marina	LDO
ZOSMR\|Gene_ORFName=ZOSMA_211G00110\|UniProtKB=A0A0K9PMP6	Zostera marina	O
MUSAM\|EnsemblGenome=Ma11_g15530\|UniProtKB=A0A804L876	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_021296mg\|UniProtKB=K3Z428	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3009G040800\|UniProtKB=C5Z000	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb417930\|UniProtKB=B6UCC8	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os05g0144800\|UniProtKB=Q6AUI3	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g00427v3\|UniProtKB=A0A0Q3JHX7	Brachypodium distachyon	O
BRADI\|EnsemblGenome=BRADI_1g78740v3\|UniProtKB=I1HAZ5	Brachypodium distachyon	O
BRADI\|EnsemblGenome=BRADI_2g36360v3\|UniProtKB=I1HLZ9	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0019930\|UniProtKB=F2CV91	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS1D02G089500\|UniProtKB=A0A3B5ZPW8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G088200\|UniProtKB=A0A3B5XWS5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G107200\|UniProtKB=A0A3B5YUE0	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_012460\|UniProtKB=A0A1U8BLA6	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110796438\|UniProtKB=A0A9R0IXI4	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HanXRQr2_Chr04g0191091\|UniProtKB=A0A9K3JCE8	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr10g0424401\|UniProtKB=A0A251TH00	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900457610\|UniProtKB=A0A9R1WVA3	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a001802mg\|UniProtKB=A0A022S1E2	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_32898\|UniProtKB=A0A2G2Y0I5	Capsicum annuum	LDO
SOLLC\|EnsemblGenome=Solyc06g008970.3\|UniProtKB=A0A3Q7HJU4	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107793390\|UniProtKB=A0A1S4A3S4	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi07g00137\|UniProtKB=F6HQ82	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_K03375\|UniProtKB=A0A059A7W8	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00089622001\|UniProtKB=A0A078FRD7	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra030524\|UniProtKB=M4EP04	Brassica campestris	LDO
ARATH\|TAIR=locus=2014525\|UniProtKB=Q8W4M7	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107912430\|UniProtKB=A0A1U8K639	Gossypium hirsutum	O
GOSHI\|Gene=LOC107914545\|UniProtKB=A0A1U8KDF1	Gossypium hirsutum	O
GOSHI\|Gene=LOC107924032\|UniProtKB=A0A1U8L597	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_004402\|UniProtKB=A0A061DQV7	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g004358mg\|UniProtKB=A0A067FRJ1	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_002G054000v3\|UniProtKB=B9GSP7	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_05G075500\|UniProtKB=A0A2C9VU83	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0558550\|UniProtKB=B9S438	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_02G082200\|UniProtKB=I1JDF1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_16G167800\|UniProtKB=I1MP75	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_2g084735\|UniProtKB=A0A072VC04	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr11_12810\|UniProtKB=A0A2I4E457	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_7G390040\|UniProtKB=A0A0A0K5Q0	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_8G242000\|UniProtKB=M5VTG6	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_269587\|UniProtKB=D8T2U1	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_91042\|UniProtKB=D8RDK7	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c10_16570\|UniProtKB=A9T079	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0059s0089\|UniProtKB=A0A2R6WTG9	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000260190\|UniProtKB=A0A1Y1HMG9	Klebsormidium nitens	LDO
KORCO\|EnsemblGenome=Kcr_1439\|UniProtKB=B1L6V6	Korarchaeum cryptofilum	O
KORCO\|EnsemblGenome=Kcr_1088\|UniProtKB=B1L5V5	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0313\|UniProtKB=Q980I2	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE3526\|UniProtKB=Q8ZSY2	Pyrobaculum aerophilum	O
PYRAE\|EnsemblGenome=PAE2991\|UniProtKB=Q8ZU14	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_2096\|UniProtKB=Q8TP28	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0335\|UniProtKB=Q8TTU0	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0942\|UniProtKB=Q58352	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_1383G\|UniProtKB=Q9HQ08	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_2476C\|UniProtKB=Q9HMM1	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_2441G\|UniProtKB=Q9HMP9	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0784\|UniProtKB=Q5JH96	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_1621\|UniProtKB=A9WBN2	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5802\|UniProtKB=O69978	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv1329c\|UniProtKB=P9WMR5	Mycobacterium tuberculosis	O
LISMO\|Gene=dinG\|UniProtKB=Q8Y604	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_22150\|UniProtKB=P50831	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_1565\|UniProtKB=Q81FL6	Bacillus cereus	O
BACSU\|EnsemblGenome=BSU_22400\|UniProtKB=P54394	Bacillus subtilis	O
GLOVI\|Gene=Q7NKM8_GLOVI\|UniProtKB=Q7NKM8	Gloeobacter violaceus	O
SYNY3\|Gene=P72618_SYNY3\|UniProtKB=P72618	Synechocystis	O
GLOVI\|Gene=Q7NN01_GLOVI\|UniProtKB=Q7NN01	Gloeobacter violaceus	O
LEPIN\|EnsemblGenome=LA_1875\|UniProtKB=Q8F513	Leptospira interrogans	O
RHOBA\|EnsemblGenome=RB8062\|UniProtKB=Q7UG83	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_358\|UniProtKB=O66684	Aquifex aeolicus	O
FUSNN\|EnsemblGenome=FN0743\|UniProtKB=Q8RFF8	Fusobacterium nucleatum	O
NEIMB\|EnsemblGenome=NMB0287\|UniProtKB=Q9K181	Neisseria meningitidis serogroup b	O
SHEON\|Gene_OrderedLocusName=SO_1819\|UniProtKB=Q8EFZ5	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_1855\|UniProtKB=Q9KQZ2	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC3950\|UniProtKB=Q8P3W9	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA1045\|UniProtKB=Q9I4S9	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM0821\|UniProtKB=Q8ZQN7	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO1206\|UniProtKB=A0A2S9PKW4	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA35465\|UniProtKB=P27296	Escherichia coli	O
GEOSL\|EnsemblGenome=GSU0363\|UniProtKB=Q74G84	Geobacter sulfurreducens	O
HAEIN\|EnsemblGenome=HI_0387\|UniProtKB=P44680	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_2081\|UniProtKB=Q8EFA4	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_1990\|UniProtKB=Q9KQK8	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC2930\|UniProtKB=Q8P6N7	Xanthomonas campestris	O
SALTY\|EnsemblGenome=STM1821\|UniProtKB=Q7CQD9	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO2071\|UniProtKB=A0A3N4B3X5	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA15617\|UniProtKB=P76257	Escherichia coli	O